Results 51 to 60 of about 11,077,430 (333)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

MUSEUM AS A VISUAL LAB? CULTURE-TECHNOLOGY NETWORKS IN CBIR PROJECTS [PDF]

Studia Humanistyczne AGH, 2017
Should any museum or scientifi c library consider itself as an information technology laboratory? This article explores the lives of several pioneering museum and library projects focused on digital image retrieval techniques (CBIR).
Joanna Gancarczyk, Anna Olszewska
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

What’s the use?: analysing student citations to provide new insights into e-book usage [PDF]

, 2014
This article reports on a small-scale user-focused piece of research carried out at the University of Sussex. In an attempt to better understand the impact of e-books on student outputs, citation analysis was performed on coursework to identify the e ...
Groves, Antony
core   +2 more sources

MicroRNA-focused CRISPR-Cas9 library screen reveals fitness-associated miRNAs

RNA: A publication of the RNA Society, 2018
MicroRNAs (miRNAs) are post-transcriptional gene regulators that play important roles in the control of cell fitness, differentiation, and development.
J. Kurata, R. Lin
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Spring 2017 [PDF]

, 2017
In this issue of the biannual Santa Clara University Library newsletter, we discuss new Library workshops focused on media literacy, and highlight Santa Clara\u27s commitment to the Open Access ...
Santa Clara University Library
core   +1 more source

On Birthing Dancing Stars: The Need for Bounded Chaos in Information Interaction [PDF]

, 2020
While computers causing chaos is acommon social trope, nearly the entirety of the history of computing is dedicated to generating order. Typical interactive information retrieval tasks ask computers to support the traversal and exploration of ...
Alzougool B., Bates M.J., Bruckman A., Buchanan G., Buchanan G., Bush V., Crabtree A., Cunningham S.J., Cunningham S.J., Czikszentmihalyi M., Dantonio L., Erdelez S., Erdelez S., Fidel R., Hinze A., Kerne A., Khoo M., Kleiner E., Kules B., Laplante A., Leong T.W., Makri S., Makri S., Mann T., McCay-Peet L., McKay D., McKay D., McKay D., McKay D., McKay D., McKay D., McKay D., McKay D., Pearce J., Purpura S., Robertson R.E., Saarti J., Sanderson M., Thudt A., Waters R., Waugh S., White R.W., Whitelaw M.   +42 more
core   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

How the Botswana International University of Science and Technology Library Engages its Stakeholders in Connecting Information Resources, Services, and Space

The International Journal of Information, Diversity, & Inclusion, 2020
In the quest to develop more innovative customer-focused library services, the Botswana International University of Science and Technology (BIUST) Library embarked on the development of robust initiatives that involved the engagement of various ...
Ayanda Agnes Lebele
doaj   +1 more source