Results 171 to 180 of about 140,665 (287)

A Ratiometric MRI Probe With a Tuned Crosslinked Network for Quantitative Imaging of Physiological pH

Small, EarlyView.
A ratiometric MRI probe comprising a paramagnetic core and a polymer shell crosslinked with tetraethylene glycol dimethacrylate enables the quantitative imaging of physiological pH. The probe shows pH‐independent r1, while pH‐responsive shell volume changes modulate r2.
Ken Kato, Akira Sumiyoshi, Kyoko Katsumata, Hiroyuki Nakamura, Koichi Kato, Kazuya Kikuchi, Satoshi Okada   +6 more
wiley   +1 more source

Multifunctional Nanoreactor Based on Catalyst Surface Engineering Combines pH‐Adaptive Catalysis With Tumor Microenvironment Modulation for Synergistic Chemodynamic‐Chemotherapy

Small, EarlyView.
A folate‐targeted Fe2O3@MoS2‐Pt/FA nanoreactor creates a localized acidic catalytic interface while simultaneously elevating intracellular H2O2 and consuming GSH. This dual regulation of reaction conditions and substrate availability markedly enhances Fenton‐driven chemodynamic therapy and synergistic chemotherapy for efficient tumor eradication ...
Yuchen Liu, Shan Lin, Pengyuan Song, Xianan Li, Jingwen Wang, Yang Zhang, Mingli Cai, Kang Fu, Ziyue Xu, Qianqian Zhao, Long Zhang, Jie Shen, Shibo Wang, Xiangdong Kong, Pu Chen   +14 more
wiley   +1 more source

Folate-Targeted polymeric micelles enhance the anti-glioma efficacy of pterostilbene in an orthotopic rat model. [PDF]

Neurotherapeutics
Yang X, Sun Y, Jin H, Zhou H, Yang Y, Su Y, Wang J, Zhao Z, Yu W, Wu M, Wang Q, Liu C, Sun W, Wang C, Wang C, Lv L, Li M, Ning J, Isakson BE, Wang Y, Shu X.   +20 more
europepmc   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

High prevalence and associated factors of red blood cell folate deficiency among first-trimester pregnant women in a neural tube defect high-risk Region of Tigray, Northern Ethiopia. [PDF]

PLoS One
Berihu BA, Mekonen HK, Mulugeta A, Magana T, Zelelow YB, Tessema M, Challa F, Belay Y, Meles M, Habtu W, Getahun T, Tolcha Y, Belay TG.   +12 more
europepmc   +1 more source

Advances in research on layered double hydroxides for biomedical applications

Smart Molecules, EarlyView.
Layered double hydroxides (LDHs) are pH‐responsive nanomaterials with broad biomedical applications. This review summarizes LDH synthesis methods and compares their advantages. It highlights LDHs' progress in cancer therapy, including chemo‐photothermal, chemo‐immunotherapy, and photodynamic‐immunotherapy combinations and their potential in bone repair.
Xinhui Yang, Zhiping Zhang, Zhao Wang, Hao Zhang, Yen Leng Pak, Yingying Jing, Yurong Guo, Fang Li, Xiao Wang, Quanxiang Han, Lei Yu, Xuejiao Li, Xing Gao, Jibin Song   +13 more
wiley   +1 more source

Cerebral folate deficiency, developmental difficulties in autism spectrum disorder and the role of leucovorin: a narrative review of mechanisms and clinical evidence. [PDF]

Drugs Context
Anuroj K.
europepmc   +1 more source

Smart mesoporous silica nanoparticles for precision cancer therapy: Tumor targeting and stimuli‐responsive controlled release

Smart Molecules, EarlyView.
Smart mesoporous silica nanoparticles integrate tunable pore structures, molecular gates, targeting ligands, and stimuli‐responsive components to achieve controlled drug release for precision cancer therapy. This review highlights design principles, therapeutic applications, and future directions in immunotherapy, biodegradability, biosafety, and ...
Majdi Al‐Amili, Lei Lei, Zhu Jin
wiley   +1 more source

Anaemia and its association with iron, vitamin B₁₂ and folate deficiency in school-age children and adolescents: a cross-sectional study of primary-care laboratory records (2019-2025). [PDF]

BMJ Paediatr Open
Erdoğan K, Doğan Tiryaki H, Kurt O, Şeker N, Küçükkelepçe O.   +4 more
europepmc   +1 more source

The Mechanism of Binding of Folate Analogues by Folate Reductase

Journal of Biological Chemistry, 1963
openaire   +2 more sources