Folate deficiency may increase the risk for elevated TSH in patients with type 2 diabetes mellitus [PDF]
BMC Endocrine Disorders, 2023 Background Type 2 diabetes mellitus (T2DM) and thyroid dysfunction (TD) are two common chronic endocrine disorders that often coexist. Folate deficiency has been reported to be related with the onset and development of T2DM.
Lin Lin +4 more
doaj +2 more sources
Serum folate deficiency and associated factors among pregnant women in Haramaya District, Eastern Ethiopia: a community-based study [PDF]
BMJ Open, 2023 Objectives We aimed to estimate the prevalence of folate deficiency and contributing factors among pregnant women.Design A community-based, cross-sectional study.Setting Haramaya District, Eastern Ethiopia.Participants Four hundred and forty-six pregnant
Masresha Tessema +16 more
doaj +2 more sources
Protective effects of pyrroloquinoline quinone in brain folate deficiency [PDF]
Fluids and Barriers of the CNS, 2023 Background Folates (Vitamin B9) are critical for normal neurodevelopment and function, with transport mediated by three major pathways: folate receptor alpha (FRα), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC).
Vishal Sangha +3 more
doaj +2 more sources
Central adiposity increases the odds for plasma folate deficiency among Chinese women of reproductive age [PDF]
Frontiers in Public Health, 2022 ObjectiveTo explore the association between adiposity and plasma folate deficiency odds among women of reproductive age in China.MethodsA cross-sectional survey on nutritional status among women of reproductive aged 18–30 years in 2005–2006 in China was ...
Jinjuan Zhang +12 more
doaj +2 more sources
Folate Deficiency Increased Lipid Accumulation and Leptin Production of Adipocytes [PDF]
Frontiers in Nutrition, 2022 Imbalanced dietary habits are closely associated with poor micronutrients status and the development of obesity. Previous studies have shown that serum folate level is decreased in obese individuals.
Chun-Wai Chan +2 more
doaj +2 more sources
Abnormal transcriptome-wide DNA demethylation induced by folate deficiency causes neural tube defects [PDF]
Frontiers in Genetics, 2022 Neural tube defect (NTDs) is one of the most common and serious fetal and neonatal birth defects. Neural tube closure (NTC) is an exquisitely coordinated process and this procedure is influenced by both genetic and environmental factor.
Shan Wang +9 more
doaj +2 more sources
One crisis, diverse impacts-Tissue-specificity of folate deficiency-induced circulation defects in zebrafish larvae. [PDF]
PLoS ONE, 2017 Folate (vitamin B9) is an essential nutrient required for cell survival, proliferation, differentiation and therefore embryogenesis. Folate deficiency has been associated with many diseases, including congenital heart diseases and megaloblastic anemia ...
Hung-Chi Tu +6 more
doaj +1 more source
The Association Between Folate and Alzheimer's Disease: A Systematic Review and Meta-Analysis
Frontiers in Neuroscience, 2021 Alzheimer's disease (AD) is the most common type of neurodegenerative disease leading to dementia in the elderly. Increasing evidence indicates that folate plays an important role in the pathogenesis of AD.
Xiaohong Zhang +19 more
doaj +1 more source
Cerebral folate deficiency [PDF]
Developmental Medicine & Child Neurology, 2004 Cerebral folate deficiency (CFD) can be defined as any neurological syndrome associated with low cerebrospinal fluid (CSF) 5-methyltetrahydrofolate (5MTHF), the active folate metabolite, in the presence of normal folate metabolism outside the nervous system.
Ramaekers, Vincent, Blau, Nenad
openaire +2 more sources
Frontiers in Molecular Neuroscience, 2023 Maternal folate deficiency increases the risk of neural tube defects (NTDs), but the mechanism remains unclear. Here, we established a mouse model of NTDs via low folate diets combined with MTX-induced conditions.
Shan Wang +9 more
doaj +1 more source