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Journal of Inherited Metabolic Disease, 2010
AbstractCerebral folate deficiency (CFD) is defined as any neurological syndrome associated with a low cerebrospinal fluid (CSF) concentration of 5‐methyltetrahydrofolate (5MTHF) in the presence of normal peripheral folate status. CFD has a wide clinical presentation, with reported signs and symptoms generally beginning at around 4 months of age with ...
Keith, Hyland +2 more
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AbstractCerebral folate deficiency (CFD) is defined as any neurological syndrome associated with a low cerebrospinal fluid (CSF) concentration of 5‐methyltetrahydrofolate (5MTHF) in the presence of normal peripheral folate status. CFD has a wide clinical presentation, with reported signs and symptoms generally beginning at around 4 months of age with ...
Keith, Hyland +2 more
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Polyneuropathy and Folate Deficiency
Archives of Neurology, 1978We studied five patients (two men and three women, age between 58 and 76 years) with clinical and electrophysiological signs of polyneuropathy. Routine neurological, hematological, and gastroenterological studies as well as procedures to test fat malabsorption were performed.
M I, Botez +3 more
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Developmental Medicine & Child Neurology, 2009
Cerebral folate deficiency (CFD) is associated with low levels of 5‐methyltetrahydrofolate in the cerebrospinal fluid (CSF) with normal folate levels in the plasma and red blood cells. The onset of symptoms caused by the deficiency of folates in the brain is at around 4 to 6 months of age.
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Cerebral folate deficiency (CFD) is associated with low levels of 5‐methyltetrahydrofolate in the cerebrospinal fluid (CSF) with normal folate levels in the plasma and red blood cells. The onset of symptoms caused by the deficiency of folates in the brain is at around 4 to 6 months of age.
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Apparent Folate Deficiency in Iron‐Deficiency Anaemia
British Journal of Haematology, 1971Summary. Examination of 50 patients with iron‐deficient hypochromic anaemia showed evidence suggesting a high incidence of folate depletion. The peripheral blood films of 44 patients (88%) showed more than 3% of neutrophils with five nuclear lobes, 35 patients (70%) had a high mean neutrophil lobe count, 20 patients (40%) had hypersegmented ...
P D, Roberts +6 more
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Sulfasalazine and Folate Deficiency
JAMA: The Journal of the American Medical Association, 1983To the Editor.— The letter entitled "Sulfasalazine and Folate Deficiency" (1983;249:729) describes an interesting case of ulcerative colitis and severe anemia with associated direct Coombs' test positivity and folate deficiency. The conclusions of the author about the relationship between sulfasalazine and folate deficiency may be misleading and have ...
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Folate Deficiency and Alcoholism
Annals of Internal Medicine, 1978Excerpt To the editor: As a medical student who looks forward to a career that includes research, I was disturbed by the letter of Dr. Chaffee (Ann Intern Med88:434, 1978). Dr.
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Folate Deficiency and Oral Contraceptives
JAMA: The Journal of the American Medical Association, 1970Orally administered contraceptive agents have become an everyday medication for many women in the United States as well as many other countries. A number of untoward effects1,2along with an ever increasing number of minor clinical or laboratory changes have been reported in women using orally administered contraceptives.2-4Recently folate deficiency ...
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Homocysteinemia due to folate deficiency
Metabolism, 1987We examined the relationship between serum folate and total homocyst(e)ine levels by determining protein-bound homocyst(e)ine in stored serum from 19 subjects with subnormal serum folate (less than 2 ng/mL), 137 subjects with low normal serum folate (between 2.0 and 3.9 ng/mL), 44 subjects with normal serum folate (between 4.0 and 17.9 ng/mL), and 38 ...
S S, Kang, P W, Wong, M, Norusis
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Folate Deficiency in Depressive Illness
British Journal of Psychiatry, 1970Two reports have shown that a substantial proportion of patients suffering from various psychiatric syndromes have low serum folate concentrations (Hunter, Jones Jones and Matthews, 1967; Carney, 1967). The present investigation was concerned to examine further the prevalence of low serum folate in a series of depressive patients on admission to ...
E H, Reynolds +3 more
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