Results 121 to 130 of about 391,837 (318)

An unexpected insight into the cause of olfactory dysfunction: fibrillogenesis of odorant-binding proteins

Cell Death Discovery
Olfactory dysfunction is a common complication of serious pathologies, including neurodegenerative disorders, bacterial and viral infections, including COVID-19, and others. Despite the widespread prevalence of olfactory disorders, the pathophysiological
Olga V. Stepanenko, Maksim I. Sulatsky, Anna I. Sulatskaya, Olesya V. Stepanenko   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Protein folding in silico : protein folding versus protein structure prediction /

, 2012
Protein folding is a process by which a protein structure assumes its functional shape of conformation, and has been the subject of research since the publication of the first software tool for protein structure prediction.
Roterman-Konieczna, Irena,editor.
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Specification and implementation of a parametricoperator: Folding

, 2008
In the early stage of creation, the architect tests his working hypotheses by making many adjustments while designing. During the sketching phase, the existing modelling tools are not compatible with the iterative nature of this process. So the challenge
J.P. Wetzel, J.C. Bignon, S. Belblidia
core  

Design, implementation and evaluation of a practical pseudoknot folding algorithm based on thermodynamics

, 2004
Reeder J, Giegerich R. Design, implementation and evaluation of a practical pseudoknot folding algorithm based on thermodynamics. BMC Bioinformatics. 2004;5(1): 104.Background: The general problem of RNA secondary structure prediction under the widely ...
Reeder Jens, Jens Reeder, Robert Giegerich, Reeder, Jens, Giegerich, Robert, Giegerich Robert   +5 more
core   +1 more source

Cathepsin B-Induced Degradation of Lysozyme Amyloid Fibrils

Proceedings
Diseases associated with the accumulation of ordered protein aggregates, amyloid fibrils, once thought to be rare, are predicted to soon become epidemics [...]
Maksim I. Sulatsky, Olga V. Stepanenko, Olesya V. Stepanenko, Ekaterina V. Mikhailova, Anna I. Sulatskaya   +4 more
doaj   +1 more source

Mesozoic Folds and Foldings in Japan

Journal of Geography (Chigaku Zasshi), 1974
Paleozoic and Mesozoic geosynclinal strata in Japan have long been thought to be very thick and to form high angled homocline. Recent studies by KIMURA and others, however, show that those strata form small scale isoclinal folds with gently folded enveloping surfaces in a large scale, and that the strata are rather thin, less than several thousand ...
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Thrusting, folding and stratigraphy of the Ghaap Group along the southwestern margin of the Kaapvaal Craton

, 1990
The lower sedimentary sequence of the Transvaal Supergroup underwent multiple folding and thrusting along the southwestern margin of the Kaapvaal Craton, between Prieska and Boegoeberg Dam.
Halbich I.W., Altermann W.
core