Frontiers in Microbiology, 2022 A high-purine diet can cause hyperuricemia and destroy the microbial composition of the gut microbiota. Both folic acid and zinc significantly reduce uric acid levels and alleviate hyperuricemia.
Xuewei Sun +15 more
doaj +1 more source
Genetically designed biomolecular capping system for mesoporous silica nanoparticles enables receptor-mediated cell uptake and controlled drug release [PDF]
, 2015 Effective and controlled drug delivery systems with on-demand release and targeting abilities have received enormous attention for biomedical applications. Here, we describe a novel enzyme-based cap system for mesoporous silica nanoparticles (MSNs) that is directly combined with a targeting ligand via bio-orthogonal click chemistry.
arxiv +1 more source
Effect of folic acid and metformin on insulin resistance and inflammatory factors of obese children and adolescents [PDF]
, 2016 Background: Considering the increasing trend of obesity, especially in developing countries such as Iran, and the role of inflammatory factors and insulin resistance (IR) in the occurrence of obesity-related complications as well as the safety of some ...
Atabek +35 more
core +3 more sources
Advanced Healthcare Materials, EarlyView.Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray +2 more
wiley +1 more source
Cholic Acid-Based Mixed Micelles as siRNA Delivery Agents for Gene Therapy [PDF]
International Journal of Pharmaceutics, 2020, 578, pp.119078Gene therapy is a promising tool for the treatment of various cancers but is hindered by the physico-chemical properties of siRNA and needs a suitable vector for the delivery of siRNA to the target tissue. Bile acid-based block copolymers offers certain advantages for the loading and delivery of siRNA since they can efficiently complex siRNA and bile ...
arxiv +1 more source
Folic acid treatment of Zambian children with moderate to severe malaria anemia. [PDF]
, 2006 Whether administration of folic acid to children with malaria anemia is helpful is controversial. Therefore, we conducted a randomised, placebo-controlled trial of 14 days of treatment with folic acid (1 mg/d) in Zambian children with malaria anemia ...
Bennett, Steve +6 more
core +2 more sources
Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy
Advanced Healthcare Materials, EarlyView.The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq +4 more
wiley +1 more source
Preconception nutrition knowledge, dietary intakes and lifestyle characteristics of Auckland women : a thesis submitted in partial fulfilment of the requirements for the degree of Master of Science in Nutritional Science at Massey University [PDF]
, 2006 Introduction Adequate nutritional status prior to conception and during early pregnancy is important in achieving a healthy pregnancy outcome. This study examined preconception nutrition knowledge, and dietary and lifestyle habits in Auckland women of ...
Proctor, Janie
core
Clinical and experimental studies on folic acid deficiency due to anticonvulsants. I. Clinical and nutritional study on megalobastic anemia due to anticonvulsants [PDF]
, 1971 Two cases of megaloblastic anemia associated with anticonvulsant drugs were studied. Both cases were inpatients of psychiatric hospitals and had quite inadequate intakes of food. The former had lung tuber. culosis and the second had febril illness before
Taguchi, Hirokuni
core +1 more source
Postgraduate Medical Journal, 1961 MACROCYTIC anamia, associated with a megaloblastic erythropoiesis, glossitis, weight loss, diarrhcra, and an absence of neurological symptoms or signs and of evidence of deficiency of vitamin B12 are usually accepted as the features of deficiency of folic acid or related pteroylglutamate compounds.
E. V. Cox, W. T. Cooke, M. J. Meynell
openaire +3 more sources