Results 161 to 170 of about 40,605 (300)

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Cobalamin, folic acid, and homocysteine

, 2009
peer-reviewedCobalamin deficiency can lead to several adverse health consequences: folate trapping in the methylation cycle and subsequent impaired DNA biosynthesis; pernicious anemia hematologically, similar to that caused by folate deficiency; elevated
SCOTT, JOHN MARTIN
core  

MAFF Suppresses Necroptosis in Pancreatic Cancer via the GATA4‐MLKL Axis

Cancer Science, EarlyView.
MAFF promotes pancreatic cancer progression by acting as a transcriptional repressor of the GATA4‐MLKL axis, thereby inhibiting necroptotic cell death. This study identifies the MAFF‐GATA4‐MLKL pathway as a novel therapeutic target and a significant prognostic biomarker for pancreatic adenocarcinoma.
Xinwei Zhou, Zheng Zhao, Ning Sun, Daoyong Zhang   +3 more
wiley   +1 more source

What Endocrinologists Should Know About Iodine: Population Deficiency, Individual Excess and Misinformation in the United Kingdom

Clinical Endocrinology, EarlyView.
ABSTRACT Iodine deficiency, once considered eliminated in the United Kingdom, has re‐emerged, particularly among women of reproductive age, in whom requirements are increased during pregnancy and lactation. The declining consumption of dairy and white fish, the emerging use of unfortified plant‐based milk alternatives, and the absence of a national ...
Peter N. Taylor, Malcolm Prentice, Sarah Bath, Emilie Combet, Nadia Schoenmakers, Vicki E. Smith, Fraser W. Gibb, Nicola Zammitt, Onyebuchi Okosieme, Kristien Boelaert, John Lazarus, Mark Vanderpump   +11 more
wiley   +1 more source

Folic acid deficiency as a modifiable risk factor for anastomotic leak in patients undergoing colorectal cancer surgery. [PDF]

Updates Surg
Chirivella-Fernandez A, Rivera-Castellano J, Ramírez-Caballero E, Morales-Díaz S, Delgado-Plasencia L.   +4 more
europepmc   +1 more source

Evaluation of a secondary care multidisciplinary clinic for adults with early‐onset type 2 diabetes at high risk in Leicester, Leicestershire and Rutland

Diabetic Medicine, EarlyView.
Abstract Background Clinical services for adults with early‐onset type 2 diabetes (EOT2D) are in urgent need of improvement. Methods We evaluated a multi‐disciplinary clinic for individuals with EOT2D at high risk (HbA1c >9%/triglyceride >20 mmol/L), providing 2–3 flexibly arranged consultations per individual between March 2024 and September 2025 ...
Jonathan Goldney, Malak Hamza, Priscilla Sarkar, Harriet Morgan, Nicole Green, James Ridgeway, Victoria Alabraba, Laura Willcocks, Krupali Chandracant, Kashmala Javed, Rhys O'Callaghan, Finley Turner, Samuel Seidu, Claire L. Meek, Melanie J. Davies   +14 more
wiley   +1 more source

A Rare Case of Severe Haemolytic Anaemia Due to Folic Acid Deficiency in a Patient with Beta Thalassaemia Trait. [PDF]

Cureus
Subair A, Rajkanna J.
europepmc   +1 more source

Association between gestational diabetes, ethnicity and migrant length of residence: An Australian cohort study

Diabetic Medicine, EarlyView.
Abstract Aims Investigate the relationship of gestational diabetes (GDM) risk for specific migrant groups compared to the Australian born of each ethnic group and length of residence (LOR) in Australia. Methods Retrospective observational cohort study from June 2020 to November 2023 at 10 Australian hospitals.
Sheila Pham, Helena Qian, James Elhindi, Olivia Byrnes, Michelle de Vroome, Geraldine Gilroy, Tanya Nippita, Gayatri Talla, Lisa White, Dipti Zachariah, N. Wah Cheung, Dharmintra Pasupathy, Sarah J. Melov   +12 more
wiley   +1 more source

Comparative Study of Laboratory Diets for Piophila casei: Beneficial Effects of Infant Formula Supplementation

Entomologia Experimentalis et Applicata, EarlyView.
The infant formula‐based diet (F), the whole powder milk diet (P), and dry‐cured ham (H) were evaluated for rearing Piophila casei. H accelerated development, promoted earlier reproduction, and achieved the highest demographic performance but showed practical limitations linked to substrate deterioration. F enhanced larval survival and adult longevity,
Diletta Missere, Maria Luisa Dindo, Antonio Martini, Alberto Lanzoni   +3 more
wiley   +1 more source

Blocking protein quality control degradation leads to structural stabilization of DHFR indel variants

The FEBS Journal, EarlyView.
Blocking protein quality control degradation by deleting the E3 ligases Ubr1 or San1 stabilizes many DHFR insertion and deletion variants that are otherwise partially unfolded. These hypomorphic variants regain folding at lower temperatures or upon methotrexate binding, revealing that PQC degradation can remove proteins that are still functionally ...
Sven Larsen‐Ledet, Caroline H. Suhr, Sarah Gersing, Celeste M. Hackney, Amelie Stein, Kaare Teilum, Rasmus Hartmann‐Petersen   +6 more
wiley   +1 more source