Results 251 to 260 of about 30,222 (286)

The Follicle Stimulating Hormone Receptor

1990
Regulation and maintenance of Sertoli cell functions essential for spermatogenesis are primarily dependent on follitropin (FSH), a glycoprotein hormone that is elaborated by the anterior pituitary gland. The initial event in follitropin action is the specific binding of the hormone by high affinity follitropin receptors present on the Sertoli cell ...
Bosukonda Dattatreyamurty, Leo E. Reichert   +1 more
openaire   +1 more source

Hormone Binding to the Follicle-Stimulating Hormone Receptor - Crystal Clear!

Experimental and Clinical Endocrinology & Diabetes, 2005
The receptors for the trophic hormones luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyrotropin (TSH) play a central role in endocrinology. These receptors face the challenge to accommodate large heterodimeric glycoprotein ligands within their extracellular hormone-binding domain.
T, Gudermann, P, Nurwakagari, D, Ben-Menahem   +2 more
openaire   +2 more sources

Follicle-stimulating hormone receptor in gynecological cancers

Molecular & Cellular Toxicology, 2018
Expression of follicle-stimulating hormone receptor (FSHR) is normally restricted to the ovary and the testis, where FSH-dependent cell differentiation occurs. FSHR also is involved in the regulation of angiogenesis in ovary. Expression of FSHR has been consistently shown in vascular endothelial cells of human malignant tumors although biological ...
Hyun Hoon Chung, Joo Chang Lee, Il Minn
openaire   +1 more source

Investigational follicle-stimulating hormone receptor agonists for male infertility therapy

Expert Opinion on Investigational Drugs, 2023
According to estimates by the World Health Organization, about 17.5% of the adult population - roughly 1 in 6 globally - experience infertility. The causes of male infertility remain poorly understood and have yet to be fully evaluated. Follicle-stimulating hormone (FSH) represents an available and useful therapeutic strategy for the treatment of ...
Rossella Cannarella, Cristina M.B. Petralia, Rosita A. Condorelli, Antonio Aversa, Aldo E. Calogero, Sandro La Vignera   +5 more
openaire   +2 more sources

Expression of Follicle-Stimulating Hormone Receptor in Vascular Anomalies

Plastic and Reconstructive Surgery, 2014
The mechanism for the growth of infantile hemangioma and vascular malformations is unknown. Follicle-stimulating hormone secretion mirrors the life cycle of infantile hemangioma and increases during adolescence, when vascular malformations often progress.
Reid A, Maclellan, Matthew P, Vivero, Patricia, Purcell, Harry P, Kozakewich, Amy D, DiVasta, John B, Mulliken, Steven J, Fishman, Arin K, Greene   +7 more
openaire   +2 more sources

Clinical efficacy of recombinant versus highly purified follicle-stimulating hormone according to follicle-stimulating hormone receptor genotype

Pharmacogenetics and Genomics, 2016
Conflicting data have been reported on the comparative doses of recombinant follicle-stimulating hormone (rFSH) and urinary highly purified follicle-stimulating hormone (HP-FSH) required for ovarian stimulation. Nothing is known about the clinical efficacy of rFSH or HP-FSH depending on the N680S follicle-stimulating hormone receptor (FSHR ...
Belén, Lledó, Patricia, Dapena, Jose A, Ortiz, Ruth, Morales, Joaquín, Llacer, Rafael, Bernabeu   +5 more
openaire   +2 more sources

Follicle‐stimulating hormone receptor expression in soft tissue sarcomas

Histopathology, 2013
AimsIn adult humans, the follicle‐stimulating hormone receptor (FSHR) is expressed only in the granulosa cells of the ovary and the Sertoli cells of the testis. Recently, it has been shown that FSHR is expressed selectively on the surface of blood vessels in a wide range of tumours.
Marcus, Renner, Benjamin, Goeppert, Muhammad Ahsan, Siraj, Aurelian, Radu, Roland, Penzel, Eva, Wardelmann, Burkhard, Lehner, Alexis, Ulrich, Albrecht, Stenzinger, Arne, Warth, Monika Nadja, Vogel, Wilko, Weichert, Peter, Schirmacher, Gunhild, Mechtersheimer, Nicolae, Ghinea   +14 more
openaire   +2 more sources

Inhibition of Follicle-Stimulating Hormone Receptor Binding by CirculatingImmunoglobulins*

The Journal of Clinical Endocrinology & Metabolism, 1982
We have characterized a circulating inhibitor of FSH receptor binding found in two patients with hypergonadotropic amenorrhea and myasthenia gravis. The inhibitor behaves as an immunoglobulin according to several criteria, including precipitation by 30% ammonium sulfate, migration on DEAE-cellulose chromatography, specific binding to protein A ...
V, Chiauzzi, S, Cigorraga, M E, Escobar, M A, Rivarola, E H, Charreau   +4 more
openaire   +2 more sources

Follicle-Stimulating Hormone Receptor Mutation and Fertility

1998
Recent studies on the molecular pathogenesis of diseases have shown that even infertility can be hereditary. This contrasts with the general opinion that infertility cannot by nature be an inherited condition. Rapid progress in the field of molecular biology has enabled the identification and detailed characterization of mutations and polymorphisms ...
T. Vaskivuo, K. Aittomäki, I. T. Huhtaniemi, J. S. Tapanainen   +3 more
openaire   +1 more source

HORMONE-REFRACTORY PROSTATE CANCER CELLS EXPRESS FUNCTIONAL FOLLICLE-STIMULATING HORMONE RECEPTOR (FSHR)

The Journal of Urology, 1999
Understanding growth regulation in hormone-refractory prostate cancer may provide avenues for novel treatment interventions. This study was conducted to characterize the expression of the receptor (FSHR) for follicle-stimulating hormone (FSH) in androgen-independent prostate cancer cell lines and in human malignant prostate tissues.Western blotting ...
E, Ben-Josef, S Y, Yang, T H, Ji, J M, Bidart, S V, Garde, D P, Chopra, A T, Porter, D G, Tang   +7 more
openaire   +2 more sources