Results 21 to 30 of about 32,216 (248)

Follicle-stimulating Hormone Interacts with Exoloop 3 of the Receptor [PDF]

Journal of Biological Chemistry, 2002
The human follicle-stimulating hormone (FSH) receptor consists of two distinct domains of approximately 330 amino acids, the N-terminal extracellular exodomain and membrane-associated endodomain including three exoloops and seven transmembrane helices.
Johann, Sohn, KiSung, Ryu, Gail, Sievert, MyoungKun, Jeoung, Inhae, Ji, Tae H, Ji   +5 more
openaire   +2 more sources

Follicle stimulating hormone and its receptor: future perspectives [PDF]

Human Reproduction, 1998
In this report, we review our present effort in the field of molecular reproductive endocrinology: to identify a small molecular weight follicle stimulating hormone (FSH) agonistic molecule. To achieve this goal we require a number of molecular tools. We have cloned and expressed the human gonadotrophin, FSH and the human FSH receptor and developed a ...
S, Chappel, D, Buckler, C, Kelton, N E, Tayar   +3 more
openaire   +2 more sources

The Expression of the Follicle-stimulating Hormone Receptor in Spermatogenesis

Recent Progress in Hormone Research, 2002
Results from experiments using mouse models suggest that the role of follicle-stimulating hormone (FSH) in spermatogenesis is the regulation of Sertoli cell proliferation and, ultimately, the size and spermatogenic capacity of the testis. The regulation of the expression of the FSH receptor (FSHR) gene is very cell specific and plays an initial role in
Heckert, Leslie L, Griswold, Michael D
openaire   +3 more sources

Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer [PDF]

Journal of Biological Chemistry, 2014
Follicle-stimulating hormone receptor (FSHR), a G-protein coupled receptor, is an important drug target in the development of novel therapeutics for reproductive indications. The FSHR extracellular domains were observed in the crystal structure as a trimer, which enabled us to propose a novel model for the receptor activation mechanism.
Jiang, Xuliang, Fischer, David, Chen, Xiaoyan, McKenna, Sean D., Liu, Heli, Sriraman, Venkataraman, Yu, Henry N., Goutopoulos, Andreas, Arkinstall, Steve, He, Xiaolin   +9 more
openaire   +2 more sources

Characterization of Constitutively Activating Eel Follicle-Stimulating Hormone Receptor

Journal of Animal Reproduction and Biotechnology, 2019
This study aimed to investigate the function of the constitutively activating mutation D540G on eel FSHR activity by in vitro functional studies. Site-directed mutagenesis was carried out to generate the D-to-G mutation at position 540 of the pcDNA3-eel ...
Jeong-Soo Kim, Munkhzaya Byambaragchaa, Kwan-Sik Min   +2 more
doaj   +1 more source

Luteinizing hormone-like and follicle-stimulating hormone-like activities of equine chorionic gonadotropin β-subunit mutants in cells expressing rat luteinizing hormone/chorionic gonadotropin receptor and rat follicle-stimulating hormone receptor

Animal Cells and Systems, 2021
To identify the specific region of eCG involved in FSH-like activity, the following mutant expression vectors were constructed targeting the amino acid residues 102–104 of the eCG β-subunit: single mutants, eCGβV102G/α, eCGβF103P/α, and eCGβR104K/α ...
Munkhzaya Byambaragchaa, Ayoung Park, So-Jin Gil, Hae-Won Lee, Yun-Jeong Ko, Seung-Hee Choi, Myung-Hwa Kang, Kwan-Sik Min   +7 more
doaj   +1 more source

Seasonal Expression of Gonadotropin Genes in the Pituitary and Testes of Male Plateau Zokor (Eospalax baileyi)

Animals, 2022
The gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH), are glycoprotein hormones in the hypothalamic-pituitary-gonadal (HPG) axis and regulate mammalian reproduction.
Kang An, Baohui Yao, Yukun Kang, Mingfang Bao, Yuchen Tan, Qiangsheng Pu, Junhu Su   +6 more
doaj   +1 more source

Effect of Bengkoang (Pachyrhizus erosus) Extract on Estrogen Receptor-?, Progesterone Receptor Expression, and Follicle-Stimulating Hormone Levels

Indonesian Journal of Obstetrics and Gynecology
Objective: Progesterone functions by inhibiting the release of Gonadotropin-Releasing Hormone (GnRH), which decreases Follicle-Stimulating Hormone (FSH) levels and converts them into hypoestrogens.
Suryanti, Mayasari Putri Ardela, Eka Frenty Hadiningsih, Sri Winarsih, Noorhamdani, Tatit Nurseta, Eviana Norahmawati   +6 more
doaj   +1 more source

The Basolateral Localization Signal of the Follicle-stimulating Hormone Receptor [PDF]

Journal of Biological Chemistry, 1998
The follicle-stimulating hormone receptor (FSHR) is physiologically localized in the basolateral compartment of the membrane of Sertoli cells. This localization is also observed when the receptor is experimentally expressed in Madin-Darby canine kidney cells. We thus used in vitro mutagenesis and transfection into these polarized cells to delineate the
Beau, Isabelle, Groyer-Picard, Marie-Thérèse, Le Bivic, André, Vannier, Brigitte, Loosfelt, Hugues, Milgrom, Edwin, Misrahi, Micheline   +6 more
openaire   +3 more sources

Role of the extracellular and intracellular loops of follicle stimulating hormone receptor in its function

Frontiers in Endocrinology, 2015
Follicle stimulating hormone receptor (FSHR) is a leucine rich repeat containing class A G-protein coupled receptor belonging to the subfamily of glycoprotein hormone receptors, which includes luteinizing hormone/choriogonadotropin receptor (LH/CGR) and ...
Antara A Banerjee, Smita D. Mahale
doaj   +1 more source