Results 81 to 90 of about 128,507 (269)

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

open access: yesAdvanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai   +12 more
wiley   +1 more source

EDC IMPACT: Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development?

open access: yesEndocrine Connections, 2018
Concern has been raised over chemical-induced disruption of ovary development during fetal life resulting in long-lasting consequences only manifesting themselves much later during adulthood.
Frederic Schrøder Arendrup   +3 more
doaj   +1 more source

Combined Effect of Follicle–Follicle Interactions and Declining Follicle-Stimulating Hormone on Murine Follicle Health In Vitro1 [PDF]

open access: yesBiology of Reproduction, 2001
Stuart J. Baker   +3 more
openaire   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

open access: yesAdvanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib   +8 more
wiley   +1 more source

The hair follicle enigma [PDF]

open access: yesExperimental Dermatology, 2017
AbstractThe hair follicle is a mini‐organ endowed with a unique structure and cyclic behaviour. Despite the intense research efforts which have been devoted at deciphering the hair follicle biology over the past 70 years, one must admit that hair follicle remains an enigma.
openaire   +2 more sources

Ovarian Cancer Diagnosis and Chemoresistance Prediction Model Based on cfRNA Molecular Signature

open access: yesAdvanced Science, EarlyView.
A deep learning model analyzes cfRNA profiles extracted from the blood of OVCA patients. This innovative approach distinguishes OVCA from healthy controls with high accuracy. Crucially, it reliably predicts patient response to chemotherapy (sensitive versus resistant subgroups).
Qinhao Guo   +14 more
wiley   +1 more source

True hermaphroditism in a wistar rat

open access: yesBrazilian Journal of Veterinary Pathology, 2009
A rare case of true hermaphroditism was observed in a 9-week-old presumed female Wistar rat. This rat did not reveal any untoward clinical signs, food consumption, body weight gain and changes in haemato-biochemical parameters.
R. Madheswaran   +7 more
doaj   +1 more source

Real‐Time in Vivo Monitoring of Circulating Endometrial Cells: Uncovering Systemic Dissemination and Temporal Fluctuations in Endometriosis

open access: yesAdvanced Science, EarlyView.
A dual‐color pseudo‐menstrual mouse model enables real‐time tracing of circulating endometrial cells (CECs) from uterine and ectopic sources. The study reveals menstrual‐phase‐dependent, burst‐like CEC release, distinct postoperative behaviors of different CEC origins, and a potential association with prolactin fluctuations, providing an in vivo ...
Shang Wang   +15 more
wiley   +1 more source

The Action of Bcl-2 Apoptotic Family Proteins and Caspases in Mediating Follicle Atresia in Adult Mouse

open access: yesScientific Papers Animal Science and Biotechnologies, 2023
Among follicles present on the surface of the ovary only a small part reach ovulation, the majority entering atresia, which is an apoptotic process regulated hormonally in general.
Liliana Petculescu-Ciochina   +2 more
doaj  

Engineering Human Donor Derived Germinal Center‐Like Organoids (GCLOs) for Studying Immune Response to Vaccination

open access: yesAdvanced Science, EarlyView.
We bioengineered a new approach methodology of generating Germinal Center Organoids that self‐organize from human blood‐derived immune cells. These immune organoids reproduce key features of humoral immunity, IgG production, and plasmablast emergence.
Bhumi Suthar   +4 more
wiley   +1 more source

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