Results 121 to 130 of about 295,380 (280)

Molecular pathophysiology of indolent lymphoma

Haematologica, 2000
Indolent lymphomas are a markedly heterogeneous group of lymphoproliferative disorders including B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma, lymphoplasmacytoid lymphoma, follicular lymphoma, mantle cell lymphoma and mucosa-associated ...
D Capello, G Gaidano
doaj  

CD93—An emerging vascular target in cancer therapy

British Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira, Stefano Barbera, Roberta Lugano, Anna Dimberg   +3 more
wiley   +1 more source

High ZFP36 Family Expression in Exhausted T Cells Is Associated With Impaired Antitumor Effector Function

Cancer Science, EarlyView.
Hypoxia induces ZFP36 family expression in exhausted CD8+ T cells, promoting the decay of AU‐rich effector cytokine mRNAs and suppressing TNF, IL2, and IFNG expression, thereby potentially contributing to impaired antitumor effector function. ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by reinvigorating antitumor ...
Li Zhu, Youki Ueda, Yu Inutsuka, Toshifumi Ninomiya, Yuka Saeki, Takashi Inozume, Hiroko Watanabe, Takamasa Ishino, Hiroyoshi Y. Tanaka, Kazuo Yamashita, Masakiyo Sakaguchi, Joji Nagasaki, Yosuke Togashi   +12 more
wiley   +1 more source

Molecular insights into the immunopathogenesis of follicular lymphoma

, 2000
Follicular lymphoma is caused by the transformation of a germinal-center-derived B cell with a t(14;18) chromosomal translocation. The distribution of somatic mutations within immunoglobulin genes indicates that follicular-lymphoma cells can interact ...
Stavroyianni, N, Kyriazopoulos, P, Papadaki, T, Stamatopoulos, K, Belessi, C, Kosmas, C   +5 more
core  

Prognostic Factors in Follicular Lymphoma

, 2020
Multiple clinical features at diagnosis have been identified as having important prognostic significance in follicular lymphoma (FL). These include the five factors included in the International Prognostic Index (IPI) which was originally developed for ...
Anna Johnston (14740420), Trotman, J (15673151)   +1 more
core  

Histological Progression of Follicular Lymphoma Associated with p53 Mutation and Rearrangement of the C-MYC Gene [PDF]

, 1996
Follicular lymphoma is a low grade malignant lymphoma. However, some follicular lymphomas undergo histological transformation into higher grade malignant lymphomas.
Imanaka, Fumio, Nanba, Koji, Kuramoto, Atsushi, Sasaki, Naomi, Takafuta, Toshiro, Takimoto, Yasuo   +5 more
core  

A Novel Plasma Biomarker hsa_circ_0080018 Drives DLBCL Progression via M2 Polarization of Tumor‐Associated Macrophages

Cancer Science, EarlyView.
The proposed mechanistic model in this study. ABSTRACT Noncoding RNAs, including circular RNAs (circRNAs), have been demonstrated to play vital roles in tumorigenesis. Uncovering the functions of circRNAs in tumorigenesis and their underlying regulatory mechanisms may suggest new approaches to the development of novel diagnostic and therapeutic ...
Yanfeng Liu, Yanan Gao, Chuanli Zhao
wiley   +1 more source

Paediatric Primary Testicular Follicular Lymphoma : A Diagnostic Challenge

Online Journal of Health & Allied Sciences
Primary testicular follicular lymphoma (PTFL) is a unique extra-nodal variant of follicular lymphoma. It is commonly seen in children and young adults. They lack evidence of the BCL2 translocation, thus biologically differ from nodal follicular lymphoma.
Aysha Suhana, Anand Vijaya Narayanan, Sangeetha Keloth Nayanar, Jithin TK, Gopakumar KG   +4 more
doaj  

BTK Inhibitor Ibrutinib Reduces Bispecific Antibody‐Related CRS Without Undermining the Anti‐Tumor Efficacy

Cancer Science, EarlyView.
BTK inhibition reprograms macrophages to suppress IL‐6/IL‐8/IL‐10‐driven CRS without compromising BsAb efficacy. ABSTRACT Bispecific antibodies (BsAbs) have shown marked efficacy in relapsed or refractory (R/R) B‐cell non‐Hodgkin lymphoma (B‐NHL). However, their clinical utility is constrained by cytokine release syndrome (CRS).
Jiaowu Cao, Dingyao Hu, Jie Lv, Jin Chai, Yue Wang, Jie Chen, Xiaoqiang Yan, Jun Zhu, Hui Yu   +8 more
wiley   +1 more source

Higher World Health Organization grades of follicular lymphoma correlate with better outcome in two Nordic Lymphoma Group trials of rituximab without chemotherapy

, 2014
A common treatment for follicular lymphoma is rituximab monotherapy. To identify patients for whom this regimen is adequate as first-line therapy, we applied the World Health Organization (WHO) classification for grading follicular lymphoma in a ...
Ostenstad, Bjorn, Wahlin, Bjorn Engelbrekt, Christensson, Birger, Jeppsson-Ahlberg, Asa, Kimby, Eva, Sander, Birgitta, Brown, Peter D., Hjalmarsson, Eric, Holte, Harald, Sundström, Christer,, Smeland, Erlend Bremertun, Sundstrom, C, Christensson, B,, Wahlin, BE, Ostenstad, B, Sander, B,, Brown, PD, Smeland, EB, Holte, H, Hjalmarsson, E,, Jeppsson-Ahlberg, A   +20 more
core   +1 more source