Results 101 to 110 of about 13,859,586 (381)

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Sutureless replacement of aortic valves with St Jude Medical mechanical valve prostheses and Nitinol attachment rings: feasibility in long-term (90-day) pig experiments [PDF]

, 2011
Objective: Nitinol attachment rings (devices) used to attach mechanical aortic valve prostheses suturelessly were studied in long-term (90 days) pig experiments.
Berreklouw, Eric, Bouchez, Stefaan, Chiers, Koen, De Somer, Filip, Koene, Bart, Taeymans, Yvo, Van Nooten, Guido   +6 more
core   +2 more sources

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

A systematic review of longitudinal cohort studies on the health of migrant populations

Social Medicine, 2016
Background: Interest in research on migrant health is increasing. The aim of this study is to review sample characteristics, study design, and outcomes (participation and retention rate) of longitudinal studies of the health of migrant populations, and ...
C. Hernando, M. Sabidó, E. Ronda, G. Ortiz-Barreda, J. Casabona   +4 more
doaj  

RESULTADOS A CORTO Y MEDIANO PLAZOS DE LA CIRUGÍA DE LA AORTA ASCENDENTE EN EL SÍNDROME DE MARFAN / Short and medium term outcomes of ascending aorta surgery in Marfan Syndrome [PDF]

CorSalud, 2013
Resumen: Introducción y objetivos: El síndrome de Marfan es un trastorno genético que provoca destrucción de las fibras elásticas de los tejidos que la contienen.
Lázaro Aldama Pérez, Rigoberto Chil Díaz, Nicolás Chao González, Manuel Naffe Abik-reck, Alejandro Villar Inclán, Osvaldo Valdés Dupeyrón   +5 more
doaj  

Six months follow up of a single intravitreal injection of ocriplasmin for symptomatic vitreomacular adhesion [PDF]

, 2016
Purpose: To evaluate the efficacy and the safety of the enzymatic vitreolysis with a single intravitreal injection of ocriplasmin 125 μg across a group of patients with symptomatic vitreomacular adhesion (sVMA) during 6 months follow up.
GUZZO, Anna Santa, Mollicone, Antonella, Nikolakopoulos, Athanasios, Nikolakopoulos, Kostantinos, PACELLA, Elena, PACELLA, FERNANDA, SECONDI, ROBERTO   +6 more
core   +2 more sources

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

An exact method for meta-analysis of case-control and follow-up studies.

Epidemiology, 2000
In this paper, we describe an exact method for estimating a common relative risk across different epidemiologic study designs. The types of studies allowed by the method include case-control studies, follow-up studies with an internal comparison group ...
D. Martin, H. Austin
semanticscholar   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Unicystic Ameloblastoma: Treatment Outcomes and Risk of Recurrence – A 19-Year Institution-Based Study

Journal of Indian Academy of Oral Medicine and Radiology
Background and Aim: Unicystic ameloblastoma (UA) is a variant of ameloblastoma; although benign, it is believed to be a destructive tumor, is locally invasive, and presents a high rate of recurrence.
Palati Sinduja, Pratibha Ramani
doaj   +1 more source