Results 161 to 170 of about 23,557,656 (289)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Follow-Up Studies of Nerve Ultrasound and Motor Conduction in Patients With Autoimmune Nodopathy. [PDF]

Muscle Nerve
Niu J, Ding Q, Tian H, Hu N, Cui L, Liu M.   +5 more
europepmc   +1 more source

Patients with stage II of the knee osteoarthritis most likely benefit from the intra-articular injections of autologous adipose tissue-from 2 years of follow-up studies. [PDF]

Arch Orthop Trauma Surg, 2023
Bąkowski P, Kaszyński J, Baka C, Kaczmarek T, Ciemniewska-Gorzela K, Bąkowska-Żywicka K, Piontek T.   +6 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

The risk of cardiovascular events in the Italian adult population without prior history of CVD: a systematic review of follow-up studies. [PDF]

Front Cardiovasc Med
Valentini I, Arcelli M, Gobbetti C, Volpi F, Conciarelli L, Boccia S, de Waure C.   +6 more
europepmc   +1 more source

A Study of Follow-Up of Poliomyelitis Patients

American Journal of Public Health and the Nations Health, 1953
H M, WALLACE, P, HEELY, M A, LOSTY, H, RICH   +3 more
openaire   +3 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Reliability and agreement of CBCT-based alveolar bone assessments for follow-up studies on adolescent orthodontic patients using multiplanar reconstruction and various CBCT units. [PDF]

Prog Orthod
Bokander Matilainen L, Johansson K, Paulsson L, Christell H.   +3 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source