Results 171 to 180 of about 23,557,656 (289)

Need for follow-up studies to better understand the relationship between the rs7041 variant and pancreatitis in COVID-19 patients. [PDF]

Rev Assoc Med Bras (1992)
Jiang ZY, Meng WJ, Li CP, He LP, Su HQ.
europepmc   +1 more source

A regularized estimation approach for case-cohort periodic follow-up studies with an application to HIV vaccine trials. [PDF]

Biom J, 2020
Zhao H, Wu Q, Gilbert PB, Chen YQ, Sun J.   +4 more
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Adjunct ketamine treatment of depression in treatment-resistant schizophrenia patients is unsatisfactory in pilot and secondary follow-up studies. [PDF]

Brain Behav, 2020
Zhuo C, Lin X, Tian H, Liu S, Bian H, Chen C.   +5 more
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Dynamic functional connectivity and coupling analysis of triple networks and white matter functional networks in first-episode schizophrenia patients: mechanisms revealed by follow-up studies. [PDF]

BMC Psychiatry
Wu X, Li Y, Hu W, Zhang Y, Li X, Kang X, Yin H, Xi Y.   +7 more
europepmc   +1 more source

Association between metabolic syndrome and prognosis of breast cancer: a meta-analysis of follow-up studies. [PDF]

Diabetol Metab Syndr, 2020
Li P, Wang T, Zeng C, Yang M, Li G, Han J, Wu W.   +6 more
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Bayesian Effect Size Ranking to Prioritise Genetic Risk Variants in Common Diseases for Follow-Up Studies. [PDF]

Genet Epidemiol
Crouch DJM, Inshaw JRJ, Robertson CC, Ng E, Zhang JY, Chen WM, Onengut-Gumuscu S, Cutler AJ, Sidore C, Cucca F, Pociot F, Concannon P, Rich SS, Todd JA.   +13 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source