Results 171 to 180 of about 3,804,186 (295)

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Adjunct ketamine treatment of depression in treatment-resistant schizophrenia patients is unsatisfactory in pilot and secondary follow-up studies. [PDF]

Brain Behav, 2020
Zhuo C, Lin X, Tian H, Liu S, Bian H, Chen C.   +5 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dynamic functional connectivity and coupling analysis of triple networks and white matter functional networks in first-episode schizophrenia patients: mechanisms revealed by follow-up studies. [PDF]

BMC Psychiatry
Wu X, Li Y, Hu W, Zhang Y, Li X, Kang X, Yin H, Xi Y.   +7 more
europepmc   +1 more source

Association between metabolic syndrome and prognosis of breast cancer: a meta-analysis of follow-up studies. [PDF]

Diabetol Metab Syndr, 2020
Li P, Wang T, Zeng C, Yang M, Li G, Han J, Wu W.   +6 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Bayesian Effect Size Ranking to Prioritise Genetic Risk Variants in Common Diseases for Follow-Up Studies. [PDF]

Genet Epidemiol
Crouch DJM, Inshaw JRJ, Robertson CC, Ng E, Zhang JY, Chen WM, Onengut-Gumuscu S, Cutler AJ, Sidore C, Cucca F, Pociot F, Concannon P, Rich SS, Todd JA.   +13 more
europepmc   +1 more source

Fertility and Reproduction after Recovery from Anorexia Nervosa: A Systematic Review and Meta-Analysis of Long-Term Follow-Up Studies. [PDF]

Diseases, 2020
Chaer R, Nakouzi N, Itani L, Tannir H, Kreidieh D, El Masri D, El Ghoch M.   +6 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Do loss to follow-up and death rates from ART care vary across primary health care facilities and hospitals in south Ethiopia? A retrospective follow-up study

, 2015
Wondu Teshome,1 Mehretu Belayneh,1 Mathewos Moges,1 Emebet Mekonnen,2 Misganu Endrias,2 Sinafiksh Ayele,2 Tebeje Misganaw,2 Mekonnen Shiferaw,2 Tigist Tesema2 1School of Public and Environmental Health, Hawassa University, 2Health Research and Technology
Mekonnen E, Endrias M, Shiferaw M, Moges M, Misganaw T, Teshome W, Ayele S, Tesema T, Belayneh M   +8 more
core