Results 141 to 150 of about 4,330,886 (309)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Type 1 diabetes, cognitive ability and incidence of cardiovascular disease and death over 60 years of follow-up time in men. [PDF]

open access: yesDiabet Med, 2022
Dybjer E   +6 more
europepmc   +1 more source

Biophysical approaches for studying viral entry

open access: yesFEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

How to Arrange Follow-Up Time-Intervals for Longitudinal Brain MRI Studies in Neurodegenerative Diseases. [PDF]

open access: yesFront Neurosci, 2021
Müller HP   +4 more
europepmc   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Replacing sedentary time with physical activity: a 15-year follow-up of mortality in a national cohort

open access: yes, 2018
Ing-Mari Dohrn,1 Lydia Kwak,2 Pekka Oja,3 Michael Sjöström,4 Maria Hagströmer1,5 1Department of Neurobiology, Care Sciences and Society (NVS), 2Institute of Environmental Medicine (IMM), Karolinska Institutet, Stockholm, Sweden; 3UKK ...
Kwak L   +4 more
core  

Familial Exudative Vitreoretinopathy: Follow-Up and Treatment Results

open access: yes, 2014
Objectives: To report the follow-up and treatment results of cases with the diagnosis of familial exudative vitreoretinopathy (FEVR) in our clinic. Materials and Methods: We retrospectively reviewed the records of 19 eyes of 10 cases of FEVR that were ...
Dilbade Yıldız Ekinci   +7 more
core   +1 more source

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