Results 71 to 80 of about 47,651 (277)

Physiologically‐Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.
ABSTRACT Pediatric extrapolation strategies issued by health authorities have streamlined pediatric drug development and reduced the unnecessary burden of conducting pediatric clinical studies. In line with these strategies, physiologically based pharmacokinetic (PBPK) models have been utilized extensively for initial dosing regimen and sampling ...
James W. T. Yates, Michael Zientek, Kunal S. Taskar, Wen Lin, Tycho Heimbach, Stefan Willmann, Jessica Rehmel, Neil Parrott, Michael Hanley, Justine Badee, Yuan Chen, Susan Cole, Loeckie De Zwart, Sebastian Haertter, Rongrong Jiang, Masakatsu Kotsuma, Guiqing Liang, Yu‐Wei Lin, Jing Liu, Ying Ou, Juliane Rascher, Naveed A. Shaik, Jan Wahlstrom, Xiaofeng Wang, Guangqing Xiao, Ka Lai Yee, S. Y. Amy Cheung   +26 more
wiley   +1 more source

Role of dispersion in pulse emission from a sliding-frequency fiber laser [PDF]

, 1995
6openopenRomagnoli, M.; Wabnitz, Stefan; Franco, P.; Midrio, M.; Bossalini, L.; Fontana, F.M., Romagnoli; Wabnitz, Stefan; P., Franco; M., Midrio; L., Bossalini; F ...
F. FONTANA, L. BOSSALINI, M. MIDRIO, M. ROMAGNOLI, P. FRANCO, WABNITZ, Stefan   +5 more
core   +1 more source

Obstetric outcome in women with congenital heart disease: A nationwide cohort in Sweden

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 1, Page 7-17, January 2026.
In this large national case–control study in women with congenital heart disease, we showed an increased likelihood of giving birth prematurely, by cesarean section, and having a small‐for‐gestational‐age neonate compared to matched controls. Abstract Introduction Survival and healthcare for patients with congenital heart disease have improved, and the
Frida Wedlund, Ellen Widing, Emma von Wowern, Christina Christensson, Sandra Lindstedt, Peder Sörensson, Aleksandra Trzebiatowska‐Krzynska, Zacharias Mandalenakis, Annika Bay, Bengt Johansson, Joanna Hlebowicz   +10 more
wiley   +1 more source

Impact of transient down-regulation of DREAM in human embryonic stem cell pluripotency: The role of DREAM in the maintenance of hESCs [PDF]

, 2016
Little is knownabout the functions of downstreamregulatory element antagonist modulator (DREAM) inembryonic stem cells (ESCs). However, DREAM interacts with cAMP response element-binding protein (CREB) in a Ca2+-dependent manner, preventing CREB ...
Aguilera, Yolanda, Capilla González, Vivian, Carrión Rodríguez, Ángel Manuel, Fontán Lozano, Ángela del Carmen, Hmadcha, Abdelkrim, Mellado, Nuria, Soria Escoms, Bernat   +6 more
core   +1 more source

Computational fluid dynamics-driven optimization of Fontan surgery from patient-specific data: A pilot study

Annals of Pediatric Cardiology
Background: Computational fluid dynamics (CFD) has been utilized to investigate the hemodynamic performance of surgical procedures, leading to enhanced outcomes.
Saurabh S. Nair, Arun Gopalakrishnan, Anoop Ayyappan, Sudip Dutta Baruah, Baiju S. Dharan, Sujesh Sreedharan   +5 more
doaj   +1 more source

Two approaches for effective modelling of rain-rate time-series for radiocommunication system simulations [PDF]

, 2006
The paper presents a model which allows to synthetically generate rain rate time-series for a fixed location. Rain rate time-series are very much correlated with signal attenuation in Ka band and above and, thus, enable to realistically simulate ...
Alasseur, Clémence, Fiebig, Uwe-Carsten, Fontán, Fernando Perez, Husson, Lionel, Mariño, P., Núñez, A.   +5 more
core  

Predicting dispersal of auto-gyrating fruit in tropical trees : a case study from the Dipterocarpaceae [PDF]

, 2015
Acknowledgments We thank the Sabah Forestry Department for access to SFR and the Rainforest Discovery Center for use of the canopy tower. JRS is funded by the Swiss National Science Foundation (SNF) grant number PDFMP3_132479/1.
Aoki, Ashton, Augspurger, Augspurger, Bagchi, Bohrer, Chesson, Connell, Curran, Damschen, Davies, Fisher, Fontan, Fox, Fox, Gelman, Green, Greene, Greene, Hanski, Hubbell, Itoh, Janzen, Kuparinen, Matlack, Maurer, Maycock, McGill, Nathan, Nathan, Nathan, Newbery, Newman, Newman, Osada, Poorter, Rees, Ridley, Seidler, Sodhi, Soons, Suzuki, Tackenberg, Tamari, Tilman, Webber, Wells, Westoby, Westoby, Whitmore, Whitmore, Wilcove, Wright   +52 more
core   +3 more sources

The physiology of thoracic duct pressure and flow: A review of the literature

Physiological Reports, Volume 14, Issue 2, January 2026.
Abstract The thoracic duct (TD) is the largest vessel of the lymphatic system, transporting interstitial fluid, macromolecules, and immune cells into the venous circulation via the lymphovenous junction. Respiratory and circulatory forces have been proposed as key drivers of TD lymph propulsion; however, the literature reports inconsistent findings ...
Sara Moazzam, Lomani A. O'Hagan, Alys R. Clarke, Peter S. Russell, Anthony R. J. Phillips, John A. Windsor, S. Ali Mirjalili   +6 more
wiley   +1 more source

Functional lymphatic reserve capacity is depressed in patients with a Fontan circulation

Physiological Reports, 2021
Background Lymphatic abnormalities play a role in effusions in individuals with a Fontan circulation. Recent results using near‐infrared fluorescence imaging disclosed an increased contraction frequency of lymphatic vessels in Fontan patients compared to
Sheyanth Mohanakumar, Benjamin Kelly, Aida Luiza Ribeiro Turquetto, Mathias Alstrup, Luciana Patrick Amato, Milena Schiezari Ru Barnabe, João Bruno Dias Silveira, Fernando Amaral, Paulo Henrique Manso, Marcelo Biscegli Jatene, Vibeke Elisabeth Hjortdal   +10 more
doaj   +1 more source

Aortic Coarctation: Recent Developments in Experimental and Computational Methods to Assess Treatments for this Simple Condition [PDF]

, 2010
Coarctation of the aorta (CoA) is often considered a relatively simple disease, but long-term outcomes suggest otherwise as life expectancies are decades less than in the average population and substantial morbidity often exists.
Feinstein, Jeffrey A., LaDisa, John F., Taylor, Charles A.   +2 more
core   +2 more sources