Results 51 to 60 of about 5,347 (131)

A Dynamic 3D Human Liver Sinusoid Model for Mechanistic Interrogation of Fontan‐Associated Liver Disease

Advanced Science, Volume 13, Issue 30, 28 May 2026.
This study presents a perfusable 3D bioengineered liver sinusoid platform that integrates biofabrication, 3D cell culture, controlled hemodynamics, and multiparametric characterization to model Fontan‐associated liver disease. By decoupling pressure and hypoxia effects, the system reveals early mechanobiological and profibrotic responses under ...
Sarah Rezapourdamanab, Mehdi Salar Amoli, Tanmay Mukherjee, Maryam Bagheri, Boeun Hwang, Linqi Jin, Yamini Singh, Sophia Norton, Ashay Vishwas Bongirwar, Shweta Karnik, Lakshmi Prasad Dasi, Reza Avazmohammadi, Rene Romero, Holly D. Bauser‐Heaton, Vahid Serpooshan   +14 more
wiley   +1 more source

Phenotyping of Fontan‐Associated Renal Physiology and Disease

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
In patients with a Fontan circulation, both kidney function and glomerular injury progressively decline with age, with a stronger decline than in healthy individuals. Additionally, intrarenal haemodynamics in patients with a Fontan circulation demonstrate decreased venous and arterial compliance, evident through elevated venous impedance and renal ...
Gaston van Hassel, Jozine M. ter Maaten, Iris E. Beldhuis, Eryn T. Liem, Bastiaan Zwart, Stephan J. L. Bakker, Rolf M. F. Berger, Joost P. van Melle   +7 more
wiley   +1 more source

Pediatric heart transplantation after a Fontan procedure

Вестник трансплантологии и искусственных органов
The Fontan procedure is a surgical technique used for hemodynamic correction of complex congenital heart defects (CHDs), and is used when radical correction of CHDs is anatomically impossible.
D. V. Ryabtsev, A. S. Ivanov, M. T. Bekov, E. A. Spirina, V. N. Poptsov, E. S. Kavardakova, A. Ch. Chartaev, S. V. Gautier   +7 more
doaj   +1 more source

The use of Macitentan in Fontan circulation: a case report

BMC Cardiovascular Disorders, 2017
Background The Fontan circulation, a result of a palliative procedure in patients with single systemic ventricles, is defined by chronically elevated pulmonary vascular resistance.
Polyvios Demetriades, Amir Aziz, Robin Condliffe, Sarah E. Bowater, Paul F. Clift   +4 more
doaj   +1 more source

Diminished liver microperfusion in Fontan patients: A biexponential DWI study. [PDF]

PLoS ONE, 2017
It has been demonstrated that hepatic apparent diffusion coefficients (ADC) are decreasing in patients with a Fontan circulation. It remains however unclear whether this is a true decrease of molecular diffusion, or rather reflects decreased ...
Hildebrand Dijkstra, Djoeke Wolff, Joost P van Melle, Beatrijs Bartelds, Tineke P Willems, Matthijs Oudkerk, Hans Hillege, Aad P van den Berg, Tjark Ebels, Rolf M F Berger, Paul E Sijens   +10 more
doaj   +1 more source

REgistry Of Catheter AbLation After Congenital Heart Disease Surgery(REAL‐CHD Registry)

Journal of Arrhythmia, Volume 42, Issue 2, April 2026.
Catheter ablation for postoperative CHD‐related arrhythmias is increasingly performed in Japan and can be achieved with acceptable safety. ABSTRACT Background Advances in surgical management have improved long‐term survival in patients with congenital heart disease (CHD), leading to a growing population of adults with postoperative arrhythmias. However,
Hitoshi Mori, Nobuhiro Nishii, Yoshiaki Kato, Takahiko Kinjo, Tsugutoshi Suzuki, Jun Yoshimoto, Shigeru Tateno, Aya Miyazaki, Hisaaki Aoki, Satoshi Higuchi, Koji Nakagawa, Keiko Toyohara, Daiji Takeuchi, Tetsuri Sakai, Kiyotaka Takefuta, Ryuta Henmi, Masayoshi Mori, Daigo Yagishita, Shun Hasegawa, Yuko Matsui, Shonosuke Watanabe, Kensuke Kikuchi, Kunihiro Kani, Yasunori Hiranuma, Toshiya Matsuyama, Kazuhisa Matsumoto, Masataka Narita, Wataru Sasaki, Taisuke Nabeshima, Kota Nagaoka, Takuro Kojima, Ritsushi Kato, Morio Shoda, Naokata Sumitomo   +33 more
wiley   +1 more source

Transparavertebral Occlusion of a Large Venovenous Collateral in a Fontan Patient

Catheterization and Cardiovascular Interventions, Volume 107, Issue 4, Page 1039-1042, March 1, 2026.
ABSTRACT Patients with a univentricular heart following completion of the Fontan circulation often experience varying degrees of desaturation due to the formation of venovenous collaterals. We present a rare case of a Fontan patient with an enlarged azygous vein shunting into the pulmonary venous system, causing significant desaturation. As no standard
Michal Jičínský, Theodor Adla, Ondřej Materna   +2 more
wiley   +1 more source

Iron deficiency and reduced exercise tolerance in adult Fontan patients

Frontiers in Pediatrics
BackgroundThe Fontan procedure allows patients with complex congenital heart defects unsuitable for biventricular repair to reach adulthood; however, it results in a non-physiological circulation characterized by chronically elevated systemic venous ...
Agnieszka Bartczak-Rutkowska, Olga Trojnarska, Sonia Nartowicz, Agata Markiewicz, Maciej Lesiak, Ewa Straburzyńska-Migaj   +5 more
doaj   +1 more source

EAM‐CT Merge Guiding a Safe Transeptal Puncture in Atrial Tachycardia Ablation in a Intracardiac Fontan Patient

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT A patient with tricuspid valve atresia and pulmonary artery valve stenosis underwent a total cavo‐pulmonary circulation with an unfenestrated intracardiac conduit. He experienced poorly tolerated atrial tachycardia and was referred for radiofrequency catheter ablation (RFCA). No interatrial shunt was evident.
Marco Scaglione, Francesco Geuna, Enrico Guido Spinoni, Andrea Lamanna, Alberto Battaglia, Marco Gagliardi, Natascia Cerrato, Domenico Caponi   +7 more
wiley   +1 more source

Dobutamine stress testing in patients with Fontan circulation augmented by biomechanical modeling.

PLoS ONE, 2020
Understanding (patho)physiological phenomena and mechanisms of failure in patients with Fontan circulation-a surgically established circulation for patients born with a functionally single ventricle-remains challenging due to the complex hemodynamics and
Bram Ruijsink, Konrad Zugaj, James Wong, Kuberan Pushparajah, Tarique Hussain, Philippe Moireau, Reza Razavi, Dominique Chapelle, Radomír Chabiniok   +8 more
doaj   +1 more source