Results 61 to 70 of about 28,671 (265)

Genetic modification of food animals [PDF]

Current Opinion in Biotechnology, 2017
Animal breeders have used a variety of methods in selective breeding programs to genetically improve food animal species. Recently this has included the use of both genetic engineering and genome editing, particularly for targeting improvement in traits for which there is no within-species or within-breed genetic variation.
openaire   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Gut morphology and blood biochemical parameters of growing pigs fed diets with a partial to total replacement of soybean meal with Arthrospira platensis

Frontiers in Veterinary Science
Soybean meal is the primary protein source in pig diets, but its production has been associated with deforestation, soil degradation, and loss of biodiversity. Arthrospira platensis (AP), a protein-rich cyanobacterium with a favorable amino acid profile,
Diana Giannuzzi, Alessandro Toscano, Gregorio Don, Rina Verdiglione, Stefano Schiavon, Luigi Gallo   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The first host plant dataset of Curculionidae Scolytinae of the world: miscellaneous tribes (Part 2)

Scientific Data
Scolytinae (Coleoptera: Curculionidae) are one of the most successful groups of invasive species. They are generally moved among continents transported within live plants, timber and wood-packaging materials.
Matteo Marchioro, Laura Besana, Michele Rossini, Davide Vallotto, Enrico Ruzzier, Giacomo Ortis, Isabel Martinez-Sañudo, Massimo Faccoli   +7 more
doaj   +1 more source

TRACESS OF ALUMINIUM IN RAW MILK AND THE EFFECT OF BOILING OF MILK AND STORAGE IN THE ALUMINIUM UTENSILS

Assiut Veterinary Medical Journal, 2009
  The level of aluminium was evaluated in raw milk sold in markets and the effect of Kitchen aluminium utensils on aluminium content of milk during boiling and storing at 4oC for different periods, the amount of aluminium was determined by atomic ...
EMAN I. EL-MOSSALAMI, SHIREEN M. NOSEIR
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Transcriptome-derived variants in milk reveal host response signatures to subclinical intramammary infection in Holstein cattle

Journal of Animal Science and Biotechnology
Background Beyond conventional transcriptome profiling, RNA-sequencing (RNA-Seq) enables the discovery of variants within expressed genes linked to complex traits such as mastitis resistance or susceptibility. In this study, RNA-Seq was performed on milk
Alice Vanzin, Vittoria Bisutti, Ángela Cánovas, Alessio Cecchinato, Luigi Gallo, Diana Giannuzzi, Sara Pegolo   +6 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source