Results 111 to 120 of about 1,848,491 (309)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Agriculture & Food SecurityBackground Understanding how price and income dynamics influence food demand across countries is essential for addressing global food security. However, food demand must be considered within the broader context of overall demand, which includes other ...
Savant Nzayiramya +2 more
doaj +1 more source
Rising demand for livestock products in India: nature, patterns and implications [PDF]
With a large population and recent growth in consumer income, India’s demand for food has increased. However, research continues to emphasise basic foods, and the demand for livestock products remains poorly understood. This study examines the demand for
Vasant, P. Ghandi, Zhang-Yue, Zhou
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Ecosystem Health and SustainabilityEcosystem services are closely associated with human well-being, and a supply–demand mismatch of ecosystem services will be detrimental to sustainable development, particularly in developing regions. The Qinghai–Gansu–Ningxia region in northwestern China
Shuwan Yan +3 more
doaj +1 more source
Implementing Rural-Urban Disaggregated Food Demand in a Partial Equilibrium Model [PDF]
Global general and partial equilibrium models focused on the agricultural sector can help policy makers do ex-ante analysis by providing a variety of macro-level outcomes, such as changes in flows of international trade, and changes in the supply, demand,
Leroy, Laetitia +3 more
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
AGGREGATE FOOD DEMAND ANALYSIS FOR A TRANSITIONAL ECONOMY: AN APPLICATION TO CHINESE HOUSEHOLD EXPENDITURE DATA [PDF]
An analytical framework to assess the effects of changing income and socio-demographic distributions on aggregate food demand functions in transitional economies is presented. Ignoring such distributional effects can lead to biased estimates of aggregate
Mittelhammer, Ronald C. +2 more
core +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Food Demand Analysis of Indonesian Households with Particular Attention to the Poorest [PDF]
The purpose of this study is to analyze the demand responses of Indonesian households to food prices, income changes and other socioeconomic factors. The underlying assumption here is that inadequate information on household food expenditure patterns ...
Pangaribowo, Evita Hanie +1 more
core +1 more source