Advanced Science, EarlyView.The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen +11 more
wiley +1 more source
Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation
Advanced Science, EarlyView.An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng +10 more
wiley +1 more source
Frontiers in PsychologyBackgroundThe economic struggles faced by many technical intern trainees in Japan include the necessity to remit money to their home country, debts owed to intermediaries facilitating their arrival, and reduced working hours due to the COVID-19 pandemic.
Tadashi Yamashita +6 more
doaj +1 more source
Perinatal Food Deprivation Modifies the Caloric Restriction Response in Adult Mice Through Sirt1. [PDF]
Front Physiol, 2021 Peña-Villalobos I +4 more
europepmc +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Food deprivation exposes sex-specific trade-offs between stress tolerance and life span in the copepod Tigriopus californicus. [PDF]
Ecol Evol, 2022 Li N, Flanagan BA, Edmands S.
europepmc +1 more source
The local evaluation of Halton's Healthy Living programme annual reach report, August 2004 - July 2005 [PDF]
, 2005 This project report discusses an evaluation of the services of Halton's Healthy Living Centre, which aims to promote good health, reduce health inequalities, and improve the health of the most disadvantaged in ...
Alford, Simon +2 more
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An Implanted Tooth That Can Feel
Advanced Science, EarlyView.To endow the implanted tooth with masticatory perception, herein we demonstrate that a 3D‐printed piezoelectric‐core/robust‐sheath implanted tooth can rebuild the sensing feedback, serving as “mechanoreceptors” in converting the mechanical chewing force to electrical signals, and up to brain through surrounding alveolar nerve system.
Yaru Cao +13 more
wiley +1 more source
Using an invertebrate model to investigate the mechanisms of short-term memory deficits induced by food deprivation. [PDF]
Behav Brain Res, 2022 Deng X, Mozzachiodi R.
europepmc +1 more source
Dimensions and Determinants of Early Childhood Health and Mortality Among American Slaves [PDF]
This paper relies on birth and death lists from plantation records to investigate the causes of low birth weight and poor health of young slave children. The sources of deprivation can be traced to the fetal period.
Richard H. Steckel
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