Tau acetylation at K331 has limited impact on tau pathology in vivo
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
The Dynamics of Food Deprivation and Overall Health: Evidence from the Canadian National Population Health Survey [PDF]
The paper explores whether the responses to food deprivation questions on the longitudinal Canadian National Population Health Survey help explain the links between socio-economic status and health.
Logan McLeod, Michael R. Veall
core +3 more sources
Effects of starvation and re-feeding on growth performance and blood plasma of rainbow trout (Oncorhynchus mykiss) [PDF]
The mechanism of compensatory growth in rainbow trout (Oncorhynchus mykiss) was studied in a completely randomized design with four experimental treatments and a control group (no food deprivation) with three replicates. Animals in treatments 1 to 4 were
Eisa Ebrahimi Dorche +2 more
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The impact of partial smokefree legislation on health inequalities: Evidence from a survey of 1150 pubs in North West England [PDF]
Background The UK government claims that between 10 and 30% of pubs and bars will be exempt from proposed legislation to achieve smokefree enclosed public places across England.
Karen Tocque +2 more
core +2 more sources
Food deprivation and reactivity to shock [PDF]
Thirty-two albino rats, under no deprivation or under severe food deprivation, were given 10 series of 12 different shock intensities, using the method of constant stimuli. Their reactions were classified into several categories. For the vocalization category, thresholds were significantly higher for the deprived group while no differences were ...
Robert J. Blanchard +1 more
openaire +1 more source
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Illumination and Food Deprivation as Determinants for Hoarding in Golden Hampsters [PDF]
It is important for animals to adapt to changes in food availability in order to survive. Hoarding is one method of accomplishing this and the golden hamster (Mesocricetus auratus) is particularly adept at hoarding.
Smith \u2702, Erin
core +1 more source
Reward context determines risky choice in pigeons and humans [PDF]
Whereas humans are risk averse for monetary gains, other animals can be risk seeking for food rewards, especially when faced with variable delays or under significant deprivation.
Ludvig, Elliot Andrew +3 more
core +3 more sources
Extinction under nine food deprivation levels1 [PDF]
One-hundred-eighty Ss received 60 acquisition trials under 22 h food deprivation and 30 extinction trials with nine different food drive levels for different groups. A regular increase in extinction running speed with drive was observed early in extinction.
John W. Cotton +2 more
openaire +1 more source

