Results 181 to 190 of about 47,916 (257)

Perilipin‐2‐Anchored Lipid Droplet‐Targeting Phototheranostics

Angewandte Chemie, EarlyView.
This study reports two NIR theranostic dyes, C‐BDP‐OH and C‐BDP‐OMe. C‐BDP‐OMe targets lipid droplets via a dual‐anchoring mechanism with PLIN2, enabling wash‐free tumor imaging. With 62.6% photothermal conversion efficiency, it achieves tumor ablation by downregulating PLIN2, disrupting LD‐mitochondria crosstalk, and triggering apoptosis and ...
Lipeng Zhang, Jiyoung Yoo, Juan Bai, Sunghyun Kim, Yesim Bakan, Yongbin Zhang, Fangjun Huo, Jingying Zhou, Caixia Yin, Jong Seung Kim   +9 more
wiley   +2 more sources

A qualitative investigation of young people's experiences and views of Early Support Hubs across England. [PDF]

PLoS One
Wright L, Griffiths JL, Appleton R, Begum S, Clarke C, Hunt NC, Lewis HK, Barnett P, Bhutta A, Driskell E, Edbrooke-Childs J, Grundy A, Hanson I, Maynard E, Mitchell L, Saunders R, Waite P, Lloyd-Evans B, Trevillion K, Johnson S.   +19 more
europepmc   +1 more source

Citrus aurantium honey‐mediated gut homeostasis and anti‐inflammation via Thorl/Nprl2‐TORC1 signaling: Network pharmacology and Drosophila validation

Animal Models and Experimental Medicine, EarlyView.
The study employed a four‐tiered strategy: (1) UHPLC‐FTMS profiling of Citrus aurantium honey to characterize its chemical composition; (2) network pharmacology analysis integrating target prediction, protein–protein interaction networks, and KEGG pathway enrichment to identify the Thor1/Nprl2‐TORC1 axis as a key mechanistic pathway; (3) in vitro ...
Wenqi Wan, Ruiguang Huang, Shuqiong Cao, Luxia Pan, Wenkai Zhang, Wujun Jiang, Zhiyong Liu   +6 more
wiley   +1 more source

Shared immune-inflammatory gene networks and drug prediction in polycystic ovary syndrome and type 2 diabetes mellitus: a bioinformatics and experimental validation study. [PDF]

Front Endocrinol (Lausanne)
Liu X, Wang Y, Bi Q, Zhang Y, Wang S, Yang P, Pei J, Zhu W, Chen Y, Zhang Z, Chen B, Zhang Q, Zhang Y, Jiang T.   +13 more
europepmc   +1 more source

Artificial Sweeteners and Autoimmune Diseases: Insights From Integrative Bioinformatics and Mendelian Randomization. [PDF]

Food Sci Nutr
Liu Y, Huang J, Hu X, Tian S, Li J, Tan S, Dong W.   +6 more
europepmc   +1 more source

The gut-brain axis in avian appetite regulation: Integrating peripheral signals with central neurocircuitry. [PDF]

Poult Sci
Mahdavi K, Zendehdel M, Ghashghaei E, Lin H.   +3 more
europepmc   +1 more source

Identification of susceptibility modules and genes through WGCNA and ceRNA network analysis in neuropathic pain-induced anxiodepression. [PDF]

Transl Psychiatry
He Y, Xu Y, Xing F, Shi X, Zhang F, Xing M, Liu Y, Zhang W, Wei X, Yuan J.   +9 more
europepmc   +1 more source

Coexpression network analysis reveals the genetic basis of divergent lipid and sugar accumulation in peanut (<i>Arachis hypogaea</i> L.). [PDF]

Food Chem (Oxf)
Umer MJ, Yu Q, Huang L, Batool R, Liu H, Li H, Li S, Hong Y, Wang R, Lu Q, Chen X.   +10 more
europepmc   +1 more source

Trends in Trust, Safety, and Health Service Access Among Women Participating in an Antiviolence Outreach Program: Protocol for a Mixed Methods Study. [PDF]

JMIR Res Protoc
Bungay V, Long PM, Guta A, Comber S, Laforet L, Tait P.   +5 more
europepmc   +1 more source

Integrated Bulk and Single-Cell Transcriptomic Analysis Reveals Xenobiotic Metabolism Genes Drive Progression From Liver Cirrhosis to Hepatocellular Carcinoma. [PDF]

Hum Mutat
Xu H, Li Y, Zhao R, Ma S, Hu N, Yu S, Lv X.   +6 more
europepmc   +1 more source