Results 101 to 110 of about 2,315,101 (308)

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Missouri Watershed Water Quality Initiative [PDF]

, 2006
This report is dedicated to Russell C. Mills in recognition of his efforts to promote whole watershed environmental and economic assessments with local stakeholder participation.
Food and Agricultural Policy Research Institute
core  

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Farm Level Economic Analysis of the Grain, Oilseed, and Cotton Provisions of the Proposed House Farm Bill (H.R. 2646) On Missouri Representative Farms FAPRI-UMC [PDF]

, 2001
This is a companion to the report which may be found at http://hdl.handle.net/10355/3162Macro and sector level data and assumptions were used to analyze the farm level economic impact to Missouri agriculture from the Proposed House Farm Bill (H.R. 2646).
Food and Agricultural Policy Research Institute
core  

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

Food Security: Self–Sufficiency of Rice in Malaysia

International Journal of Management Studies, 2011
Malaysia’s stance on food security is largely translated in terms of achieving self-sufficiency in rice production at about 65-70% of the local consumption. Since Malaysia does not have the comparative advantage in rice production, it implements a wide
Fatimah Mohamed Arshad, Emmy Farha Alias, Kusairi Mohd Noh, Muhammad Tasrif   +3 more
doaj  

FAPRI Analysis of Stricter Payment Limitations: Additional Information [PDF]

, 2003
The testimony which this accompanies may be found at http://hdl.handle.net/10355/3133Document in support of the testimony given by Pat Westhoff to the Commission on the Application of Payment Limitations in Washington ...
Food and Agricultural Policy Research Institute
core  

Optimal Grazing Exclusion Duration to Enhance Soil Carbon Sequestration in Degraded Grasslands

Advanced Science, EarlyView.
Across China, grazing exclusion reaches the national mean soil organic carbon recovery benchmark sooner in high‐MAP regions (> 500 mm), but recovery is much slower where MAP < 300 mm. Scaling this strategy to 70% of China's degraded grasslands would sequester about 1.52 Pg of soil carbon over 10 years—roughly 17% of annual global fossil‐fuel emissions.
Bin Zhang, Chongzhi Sun, Dongmei Xue, Paul Christiaan Struik, Tongrui Zhang, Jiayue Liu, Tingting Xing, Ziyang Liu, Shiming Tang, Ke Jin   +9 more
wiley   +1 more source

Governance of the wildlife trade and the prevention of emerging zoonoses: a mixed methods network analysis of transnational organisations, silos, and power dynamics

Globalization and Health
Introduction The wildlife trade is an important arena for intervention in the prevention of emerging zoonoses, and leading organisations have advocated for more collaborative, multi-sectoral approaches to governance in this area. The aim of this study is
Chloe Clifford Astbury, Anastassia Demeshko, Eduardo Gallo-Cajiao, Ryan McLeod, Mary Wiktorowicz, Cécile Aenishaenslin, Katherine Cullerton, Kirsten M. Lee, Arne Ruckert, A. M. Viens, Peter Tsasis, Tarra L. Penney   +11 more
doaj   +1 more source

Getting Ahead of the Game: Experiential Learning for Groundwater Governance in Ethiopia

International Journal of the Commons
Groundwater management is highly complex, with many users sharing the same resource often with limited understanding of their interconnectedness. Behavioral experiments (games) that simulate real-life common-pool resource use have shown promise as an ...
Hagar ElDidi, Wei Zhang, Ivy Blackmore, Fekadu Gelaw, Caterina De Petris, Natnael Teka, Seid Yimam, Dawit Mekonnen, Claudia Ringler, Ruth Meinzen-Dick   +9 more
doaj   +1 more source