Advanced Science, EarlyView.ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang +6 more
wiley +1 more source
When parasocial relationships meet food technology neophobia: understanding consumer responses to virtual influencer marketing of upcycled foods. [PDF]
Front NutrLi Y, Chen X.
europepmc +1 more source
Quality Management and Improvement in the Spanish SME Food Industry: The Adoption of ISO 9000 [PDF]
This paper presents the results of a large-scale study in the Spanish F&DI aimed to identify the motivators, perceived costs, and benefits of implementing ISO 9000 standards. Results indicate the increasing importance of ISO 9000 standards as a strategic
Arribas, Nuria +4 more
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Integrating Ecology and Economics in Agent‐Based Models to Support Agricultural Policy
Advanced Science, EarlyView.Agent‐based models are valuable tools for studying social‐ecological systems in agriculture. This review maps how existing agent‐based models represent the human and natural domains of agriculture, and discusses developments in economic and ecological agent‐based modeling.
Daniel Vedder +5 more
wiley +1 more source
Shrinking appetites: Will GLP-1 adoption in high-income countries accelerate Big Food's push into low- and middle-income countries? [PDF]
Global HealthEven B +5 more
europepmc +1 more source
A mosaic type of development - the Agri-food Districts experience in Italy [PDF]
The Italian Industrial Districts (IDs) are now considered in the national and international literature as one of the main factors of the successful and rapid industrial development of Italy after the Second World War. In this paper we outline the general
Fanfani, Roberto, Brasili, Cristina
core
Advanced Science, EarlyView.Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu +13 more
wiley +1 more source
Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV
Advanced Science, EarlyView.Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes +14 more
wiley +1 more source
Biologically inspired optimization of construction sector eco industrial park networks using food web metrics. [PDF]
Sci RepGenc O, Kurt A.
europepmc +1 more source
A Critical Time Window of Neocortex Modulation for Remote Fear Memory in Rats and Humans
Advanced Science, EarlyView.This study identifies a delayed consolidation window around 18 h after fear learning in the mPFC essential for remote fear memory. VTA dopaminergic input during this window sustains remote memory in rats, while non‐invasive stimulation of homologous human mPFC at the corresponding time selectively weakens remote but not recent fear memory, revealing a ...
Lu Cao +19 more
wiley +1 more source