Results 191 to 200 of about 20,027 (238)

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Linking Fire, Food Webs, and Fish in Stream Ecosystems. [PDF]

Ecosystems
Roon DA, Bellmore JR, Benjamin JR, Robinne FN, Flitcroft RL, Compton JE, Ebersole JL, Dunham JB, Bladon KD.   +8 more
europepmc   +1 more source

Safety concerns reported by coroners following fentanyl patch fatalities in England, Wales and Northern Ireland between 1997 and 2024

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim To identify safety concerns reported by coroners following fentanyl patch‐related deaths in England, Wales and Northern Ireland, and determine differences in coronial reporting. Methods A systematic case series linking the National Programme on Substance Use Mortality (NPSUM) and the Preventable Deaths Tracker (PDT) (https ...
Eman Mshari, Caroline S. Copeland, Georgia C. Richards   +2 more
wiley   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

N‐acetylcysteine for non‐paracetamol‐induced acute liver failure in children: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Non‐surgical treatment of acute liver failure (ALF) is primarily supportive and depends on the underlying cause. While N‐acetylcysteine (NAC) is proven effective in paracetamol‐induced ALF, its potential benefits in non‐paracetamol ALF for paediatric patients remain unclear.
Alise D. E. de Groot, Désanka M. Stoppels, Arno R. Bourgonje, Willemien F. J. Hof, Martin C. J. Kneyber, Daan J. Touw, Henkjan J. Verkade, Paola Mian   +7 more
wiley   +1 more source

Seasonal Shifts in Trophic Interaction Strength Drive Stability of Natural Food Webs. [PDF]

Ecol Lett
Gaedke U, Li X, Guill C, Hemerik L, de Ruiter PC.   +4 more
europepmc   +1 more source

String Figuring young children's perspectives of quality in English early childhood education and care

British Educational Research Journal, EarlyView.
Abstract Quality in early childhood education and care (ECEC) is a contested concept and has generally been conceptualised by inter‐related indicators such as staff qualifications, educational environment, policy or child‐to‐staff ratios. There has been a more limited emphasis on how young children might perceive and experience quality.
Nikki Fairchild, Éva Mikuska
wiley   +1 more source

Digestive contents and food webs record the advent of dinosaur supremacy. [PDF]

Nature
Qvarnström M, Vikberg Wernström J, Wawrzyniak Z, Barbacka M, Pacyna G, Górecki A, Ziaja J, Jarzynka A, Owocki K, Sulej T, Marynowski L, Pieńkowski G, Ahlberg PE, Niedźwiedzki G.   +13 more
europepmc   +1 more source

Methane fueled lake pelagic food webs in a Cretaceous greenhouse world. [PDF]

Proc Natl Acad Sci U S A
Sun F, Luo G, Pancost RD, Dong Z, Li Z, Wang H, Chen ZQ, Xie S.   +7 more
europepmc   +1 more source

Long-term data reveal widespread phenological change across major US estuarine food webs. [PDF]

Ecol Lett
Fournier RJ, Colombano DD, Latour RJ, Carlson SM, Ruhi A.   +4 more
europepmc   +1 more source