Results 101 to 110 of about 258,063 (305)

Effects of regional differences and demography in modelling foot-and-mouth disease in cattle at the national scale [PDF]

, 2019
Foot-and-mouth disease (FMD) is a fast-spreading viral infection that can produce large and costly outbreaks in livestock populations. Transmission occurs at multiple spatial scales, as can the actions used to control outbreaks. The US cattle industry is
Beck-Johnson, Lindsay M., Hallman, Clayton, Lindström, Tom, Miller, Ryan S., Murrieta, Deedra J., Portacci, Katie, Sellman, Stefan, Tildesley, Michael J., Tsao, Kimberly, Webb, Colleen T.   +9 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Re-emergence of foot-and-mouth disease in the Republic of Korea caused by the O/ME-SA/Ind-2001e lineage

Frontiers in Veterinary Science
The O/ME-SA/Ind-2001e foot-and-mouth disease virus (FMDV) lineage is a pandemic strain that has recently become dominant within East and Southeast Asia. During May 2023, this viral lineage spread to the Republic of Korea, where 11 outbreaks were detected
Soyoon Ryoo, Hyeonjeong Kang, Da-Rae Lim, Jae-Myung Kim, Youngwoo Won, Ji Ye Kim, Donald P. King, Antonello Di Nardo, Sang-Ho Cha   +8 more
doaj   +1 more source

NQO1‐Mediated Anoikis Resistance and Immune Evasion Define a High‐Risk Multi‐Omic Subtype for Precision Management of T1 High‐Grade Bladder Cancer

Advanced Science, EarlyView.
Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo, Chunru Xu, Shufan Fu, Qiang Cheng, Juan Li, Linkuo Shang, Gaojie Li, Yang Yang, Ying Wang, Yanqing Gong, Shengwei Xiong, Jian Fan, Changwei Yuan, Mei Zhang, Yifan Zuo, Elena Papaleo, Yue Shi, Yuan Liang, Xuesong Li, Hongzhao Li, Weimin Ci   +20 more
wiley   +1 more source

Rapid Effective Trace-Back Capability Value in Reducing the Cost of a Foot and Mouth Disease Event [PDF]

This study evaluates how the availability of animal tracing affects the cost of a hypothetical Foot and Mouth Disease (FMD) outbreak in the Texas High Plains using alternative tracing scenarios.
Anderson, David P., Hagerman, Amy D., Looney, J. Chris, McCarl, Bruce A., Ward, Michael P.   +4 more
core   +1 more source

Neuromodulator Dynamics Underlying Associative Learning in the Ventral Striatum's Olfactory Tubercle

Advanced Science, EarlyView.
Using fiber photometry and genetically encoded sensors, the dynamic release patterns of four neuromodulators in the olfactory tubercle (OT)—a brain region overlapping with the olfactory cortex and ventral striatum—were systematically monitored in response to external rewards and distinct reward‐associated learning processes.
Maojun Hong, Liuting Zou, Yiqing Chen, Juan Guo, Zhixiang Xu, Tong Ma, Shuaishuai Hu, Rongfeng K. Hu   +7 more
wiley   +1 more source

The pH stability of foot-and-mouth disease virus

Virology Journal, 2017
ᅟ This review summarized the molecular determinants of the acid stability of FMDV in order to explore the uncoating mechanism of FMDV and improve the acid stability of vaccines.
Hong Yuan, Pinghua Li, Xueqing Ma, Zengjun Lu, Pu Sun, Xingwen Bai, Jing Zhang, Huifang Bao, Yimei Cao, Dong Li, Yuanfang Fu, Yingli Chen, Qifeng Bai, Jie Zhang, Zaixin Liu   +14 more
doaj   +1 more source

Foot-and-mouth disease virus

Comparative Immunology, Microbiology and Infectious Diseases, 2002
Foot-and-mouth disease virus (FMDV) is an aphthovirus of the family Picornaviridae and the etiological agent of the economically most important animal disease. As a typical picornavirus, FMD virions are nonenveloped particles of icosahedral symmetry and its genome is a single stranded RNA of about 8500 nucleotides and of positive polarity.
Domingo, Esteban, Escarmís, Cristina, Sobrino, Francisco, Baranowski, Eric   +3 more
openaire   +5 more sources

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Bioinformatics based design of thermostable virus-like particles-based vaccine for foot-and-mouth disease serotype A and in-vivo evaluation in guinea pigs

Frontiers in Cellular and Infection Microbiology
BackgroundFoot-and-mouth disease (FMD) is a contagious disease affecting cloven footed animals. Existing vaccines although effective, has limitations of short immunity, needs cold chain maintenance, high biosafety levels facilities for production and ...
Deepak Praveen Raj Selvaraj, Paramasivam Saravanan, Aparna Madhavan, Das Adwitiya, Chandan Tilak, Beeragere Parameshwaraiah Sreenivasa, Shreya Gopinath, Sekar Elackiya, Saravanamuthu Thiyagarajan, Pallab Chaudhuri   +9 more
doaj   +1 more source