Results 101 to 110 of about 31,530 (255)

Long‐read sequencing of recurrent FGF12 duplications in epilepsy: Insights into structural mechanisms and aberrant isoforms

Epilepsia, EarlyView.
Abstract Objective Fibroblast growth factor 12 (FGF12), a member of the fibroblast homologous factor family, plays a key role in the modulation of voltage‐gated sodium (Nav) channels. Pathogenic variants in the FGF12 gene leading to a gain‐of‐function mechanism and partial duplication encompassing the FGF12 gene leading to a loss‐of‐function mechanism ...
Jade Fauqueux, Laurence Chaton, Pierre Cleuziou, Anne‐Sophie Diependaële, Nathalie Bach, Nicolas Gruchy, Marion Gerard, Jean‐Pascal Meneboo, Céline Villenet, Martin Figeac, Emilie Ait‐Yahya, Caroline Thuillier, Elise Boudry, Adeline Trauffler, Sylvie Nguyen‐The‐Tich, Simon Boussion, Roseline Caumes, Jamal Ghoumid, Thomas Smol   +18 more
wiley   +1 more source

Chronic hepatitis in horses with persistent equine hepacivirus infection

Equine Veterinary Journal, EarlyView.
Abstract Background Equine hepacivirus (EqHV) is closely related to hepatitis C virus (HCV), which causes persistent infection and chronic hepatitis in people. Information on persistent EqHV infection and hepatitis is limited. Objectives To report 19 cases of chronic hepatitis and persistent EqHV infection.
Mason C. Jager, Daniela Luethy, Samantha Shallop, Jessica Cathcart, Thomas J. Divers, Jean‐Yin Tan, Erin McConachie Beasley, Philip Johnson, Laurence Leduc, Claire Smith, Camilla Anne Jamieson, K. Gary Magdesian, Gerlinde R. Van de Walle, Joy E. Tomlinson   +13 more
wiley   +1 more source

Structures of foot and mouth disease virus pentamers: Insight into capsid dissociation and unexpected pentamer reassociation

, 2017
N. N. Malik, Abhay Kotecha, Sarah Gold, Amin S. Asfor, Jingshan Ren, Juha T. Huiskonen, Tobias J. Tuthill, Elizabeth E. Fry, David I. Stuart   +8 more
openalex   +1 more source

Clinical Outcomes of Reduced‐Dose Cabozantinib as Third‐ or Later‐Line Therapy After Immune Checkpoint Inhibitors in Advanced Hepatocellular Carcinoma: A Real‐World Study

Hepatology Research, EarlyView.
In this real‐world post‐ICI setting, cabozantinib demonstrated meaningful clinical activity even at reduced doses, with disease control achieved in nearly half of patients. Importantly, preserved liver function (Child–Pugh class A) was the only determinant of both disease control and overall survival.
Teiji Kuzuya, Hisanori Muto, Yoshihiko Tachi, Mizuki Ariga, Sayaka Morisaki, Gakushi Komura, Takuji Nakano, Hiroyuki Tanaka, Kazunori Nakaoka, Eizaburo Ohno, Kohei Funasaka, Mitsuo Nagasaka, Ryoji Miyahara, Yoshiki Hirooka   +13 more
wiley   +1 more source

Isolation of SAT2 Foot and Mouth Disease Virus in Iraq

The Iraqi Journal of Veterinary Medicine
Foot-and-mouth disease (FMD) is a highly contagious viral disease affecting cloven-hoofed animals, causing significant economic losses in livestock industries. The causative agent, Foot-and-Mouth Disease Virus (FMDV), consists of seven serotypes: O,
Ghazwan K AL-Anbagi, Aida B Allawe
doaj   +1 more source

Interpretative Phenomenological Study Exploring Why People With Kidney Failure Say ‘No’ to a Kidney Transplant

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To develop an in‐depth understanding of peoples' perceptions and experiences of decision‐making and reasons why they declined the opportunity of a kidney transplant. Design The Theory of Planned Behaviour informed the qualitative interpretative phenomenological analysis. Methods Semi‐structured interviews were conducted between August 2022
Emma Jones, Leah McLaughlin, Kate Shakespeare, Jane Noyes   +3 more
wiley   +1 more source

Removal of the genome-linked protein of foot-and-mouth disease virus by rabbit reticulocyte lysate [PDF]

, 1981
D. V. Sangar, James Bryant, Timothy Harris, F. Brown, David J. Rowlands   +4 more
openalex   +1 more source

Cryoglobulinemia: An update on classification, pathophysiology, clinical presentation, and management

Journal of Internal Medicine, EarlyView.
Abstract Cryoglobulinemia (CG) is defined by the presence of serum immunoglobulins that precipitate below 37°C and redissolve upon rewarming. It is classified into three types based on immunoglobulin composition. Type I, a rare form, involves monoclonal IgM or IgG and is linked to lymphoproliferative disorders.
Anna Linda Zignego, Laura Gragnani, Marcella Visentini, Riccardo Bomben, Luca Arcaini, Clodoveo Ferri, Valter Gattei, Cesare Mazzaro   +7 more
wiley   +1 more source

Use of virus-like particles and nanoparticle-based vaccines for combating picornavirus infections

Veterinary Research
Picornaviridae are non-enveloped ssRNA viruses that cause diseases such as poliomyelitis, hand-foot-and-mouth disease (HFMD), hepatitis A, encephalitis, myocarditis, and foot-and-mouth disease (FMD).
Mei Ren, Sahibzada Waheed Abdullah, Chenchen Pei, Huichen Guo, Shiqi Sun   +4 more
doaj   +1 more source

The Role of Viruses in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte, Jørgen Slots, Henrik Dommisch   +2 more
wiley   +1 more source