Results 41 to 50 of about 2,205,957 (345)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Brutalidade antiga: sobre história e ruína em Euclides

Estudos Avançados, 1996
Este artigo analisa um dos aspectos menos enfatizados nas interpretações correntes sobre a obra de Euclides da Cunha: sua filiação às tendências estéticas e à concepção de mundo do Romantismo, muito marcante na literatura e cultura brasileiras da segunda
Francisco Foot Hardman
doaj   +1 more source

Comparison of Calcaneal Subchondral Injection of Calcium Phosphate and Plantar Fasciotomy vs Plantar Fasciotomy Alone for Refractory Infracalcaneal Heel Pain

Foot & Ankle Orthopaedics, 2021
Background: Treatment of chronic refractory heel pain has evolved to consider calcaneal structural fatigue as a component of the symptom profile. While concomitant calcium phosphate injection has become a method of addressing the accompanying calcaneal ...
Michael Matthews DPM, Erin Klein DPM, Zachary Hulst BS, Neathie Patel BS, Lowell Weil DPM, MBA, Matthew Sorensen DPM, Adam Fleischer DPM, MPH   +6 more
doaj   +1 more source

Dissipative dark matter halos: The steady state solution

, 2018
Dissipative dark matter, where dark matter particle properties closely resemble familiar baryonic matter, is considered. Mirror dark matter, which arises from an isomorphic hidden sector, is a specific and theoretically constrained scenario.
Foot, R.
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Complete coding region sequence analyses and antigenic characterization of emerging lineage G-IX of foot- and-mouth disease virus serotype Asia1

Veterinary Quarterly
Foot-and-mouth disease Virus (FMDV) serotype Asia1 is prevalent in the Indian subcontinent, with only G-III and G-VIII reported in India until 2020. However, in 2019, a novel genetic group within serotype Asia1, designated as G-IX, emerged in Bangladesh,
Manoranjan Rout, Shyam Singh Dahiya, Saravanan Subramaniam, Ramakant Acharya, Reshama Samanta, Jitendra Kumar Biswal, Jajati Keshari Mohapatra, Rabindra Prasad Singh   +7 more
doaj   +1 more source

Staged management of a large ischemic heel ulcer in a diabetes patient: a case report

Frontiers in Endocrinology, 2023
Heel ulcer is one of the severe complications of patients with diabetes mellitus, which poses a high risk for foot infection and amputation, especially in patients with peripheral arterial disease and neuropathy.
Yuedong Chen, Hui Yang, Wei Wang, Yinchen Chen, Dong Jiang, Yihui Li, Liyi Li, Wengbo Yang, Aiping Wang   +8 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

VIA RASELLA, 1944: MEMORY, TRUTH, AND HISTORY [PDF]

, 2000
The facts: what happened? On 23 March 1944, a column of 156 police troops from the Bolzen regiment attached to the German army were marching through the centre of occupied Rome.
Foot, J
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source