Results 51 to 60 of about 8,896,354 (231)

The associations of leg lean mass with foot pain, posture and function in the Framingham foot study

Journal of Foot and Ankle Research, 2014
Background Foot disorders are common in older adults and associated with impaired lower extremity function. Reduced muscle mass may play a role in the etiology of foot disorders and consequent poor function.
Robert R McLean, Alyssa B Dufour, Patricia P Katz, Howard J Hillstrom, Thomas J Hagedorn, Marian T Hannan   +5 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Validation of the Chinese Manchester foot pain and disability index (C-MFPDI) among patients with inflammatory arthritis

Journal of Foot and Ankle Research, 2019
Background The Manchester Foot Pain and Disability Index (MFPDI) is a patient-reported outcome tool used to measure foot pain and foot-related disability.
Brina Xing Ying Erh, Hong-gu He, Kate Frances Carter, Peter P. Cheung, Daphne S. Tan, Wenru Wang, Keith Rome   +6 more
doaj   +1 more source

Fusion Rates in Tibiotalocalcaneal Arthrodesis with Tantalum Coated Metal Cup Augmentation

Foot & Ankle Orthopaedics, 2023
Category: Ankle Arthritis; Ankle Introduction/Purpose: Tantalum coated metal spacers (TCMS) have recently been utilized to fill and provide structure to large bony defects in the hindfoot.
Vineeth Romiyo BS, Adel Mahjoub MD, Pietro Gentile BS, Erik Freeland DO   +3 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Minimalist versus conventional running shoes : effects on lower limb injury incidence, pain and muscle function experienced distance runners [PDF]

, 2013
Includes abstract.Includes bibliographical references.The aim of this randomised clinical trial over 12 weeks was to determine if the gradual transition (accompanied by calf muscle training), from conventional to minimalist running shoes 1) increased the
Marshall, Charlene
core   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Reliability and validity of foot function index in flatfeet of children and adolescents

Zhongguo kangfu lilun yu shijian
Objective To determine the reliability and validity of foot function index (FFI) in children and adolescent with flatfeet. Methods From January, 2023 to June, 2024, among the patients with flatfeet aged seven to 18 years who were treated at the 3D ...
FENG Haiyang
doaj   +1 more source

Pressure and pain In Systemic sclerosis/Scleroderma - an evaluation of a simple intervention (PISCES): randomised controlled trial protocol

BMC Musculoskeletal Disorders, 2012
Background Foot problems associated with Systemic Sclerosis (SSc)/Scleroderma have been reported to be both common and disabling. There are only limited data describing specifically, the mechanical changes occurring in the foot in SSc.
Alcacer-Pitarch Begonya, Buch Maya H, Gray Janine, Denton Christopher P, Herrick Ariane, Navarro-Coy Nuria, Collier Howard, Loughrey Lorraine, Pavitt Sue, Siddle Heidi J, Wright Jonathan, Helliwell Philip S, Emery Paul, Redmond Anthony C   +13 more
doaj   +1 more source