Results 181 to 190 of about 4,026,639 (227)

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

Flatfoot vs Pronation: Structural and Functional Dissociation Between Foot Posture and Foot Physiology. [PDF]

Foot Ankle Orthop
Origo D, Tramontano M, Montini G, Dal Farra F.   +3 more
europepmc   +1 more source

Metal‐Half‐Salen Chemistry for One‐Pot Mineralization on Hydrophobic Polymer Membranes

Advanced Science, EarlyView.
Here we report a versatile one‐pot synthetic strategy for organic–inorganic composite membranes, which leverages a metal half‐Salen system to precisely govern the competing kinetics of coordination and hydrolysis. In contrast to conventional two‐step metal‐phenol chemistries, our integrated approach substantially simplifies the fabrication process ...
Rou‐Ming Wen, Hao Ye, Ming‐Bang Wu, Lu‐Lin Ma, Qi‐Hui Ye, Zi‐Hao Yuan, Yi Xie, Juming Yao, Hao‐Cheng Yang   +8 more
wiley   +1 more source

Cushioned Insoles for First Metatarsophalangeal Joint Osteoarthritis: Protocol for the SOLE Randomised Controlled Trial. [PDF]

J Foot Ankle Res
Paterson KL, Bennell KL, Bryant A, Li P, De Silva AP, Shearer S, Hinman RS.   +6 more
europepmc   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

The "Hand as Foot" teaching method for ocular anatomy: an embodied learning approach. [PDF]

Front Med (Lausanne)
Qi M, Yang X.
europepmc   +1 more source

Innovative Test Strip‐Based Colorimetric Sensors Integrated With Affinity Chromatography: Acetylcholinesterase Inhibitor Screening Breakthrough in Lycium Barbarum Leaves

Advanced Science, EarlyView.
Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa, Hui Yuan, Jingui Ma, Zhigang Yang, Mei Wang, Weibiao Wang, Lingling Yang, Fen Ma, Weiman Zhang, Gidion Wilson Mening'oo, Guoning Chen, Xueqin Ma   +11 more
wiley   +1 more source

The Spine-Foot Connection: Investigating Compensatory Mechanisms in Degenerative Spine Disease Through Foot Deformity Patterns. [PDF]

Medicina (Kaunas)
Halayqeh S, Kaidi A, Asada T, Singleton Q, Carney D, Qureshi S, Iyer S.   +6 more
europepmc   +1 more source

Endothelial YAP Signaling Promotes Blood‐Spinal Cord Barrier Repair in Mice After Spinal Cord Injury

Advanced Science, EarlyView.
Endothelial YAP is required for blood‐spinal cord barrier repair after spinal cord injury. YAP‐dependent vascular repair is associated with ANGPT1/PI3K/AKT signaling in vivo and may involve endothelial‐pericyte paracrine interactions. By supporting vascular remodeling, tight junction restoration, restored pericyte coverage, and astrocyte‐vascular ...
Jiawei Wang, Yaozhi He, Yanjiao Wang, Jingjing Zhang, Qishun Liang, Mengxian Jia, Yumin Wu, Zongjie Yuan, Ziwei Fan, Yuxuan Li, Huihui Zhang, Qinjiao Fu, Ying Wang, Zhihui Huang, Honglin Teng   +14 more
wiley   +1 more source

Effects of different foot orthoses on muscular frequency spectrum during the swing phase of gait following ACL reconstruction: a cross-sectional, mixed-model within-subject study. [PDF]

BMC Sports Sci Med Rehabil
Piri E, Jafarnezhadgero A.
europepmc   +1 more source