Results 51 to 60 of about 41,923 (267)

Effect of Topical Insulin on Diabetic Wound Healing among Patients with Diabetic Foot Ulcer [PDF]

Egyptian Journal of Health Care, 2019
Diabetic foot ulcer is a debilitative disease with severe consequences in diabetic patients. Woundhealing is a complex biological process that restores skin integrity. Conventional dressings werefound ineffective for these ulcers.
Hoda Abdou Abd El-Monem El-Deeb, Noura Mahmoud Elrefaey   +1 more
doaj   +1 more source

Pemt Inhibition‐Mediated Vdac1 Oligomerization Regulates Mitochondrial Dysfunction, Apoptosis, and Inflammation in High‐Fat Diet‐Derived Liver Injury

Advanced Science, EarlyView.
ABSTRACT High‐fat diet (HFD)‐induced hepatic injury represents a pathology observed across vertebrates, yet the underlying mechanisms remain incompletely understood. Herein, the present study identifies phosphatidylethanolamine methyltransferase (Pemt), a key enzyme in phosphatidylcholine synthesis, as a critical regulator of mitochondrial homeostasis ...
Xianyong Bu, Xiufei Cao, Xin Yao, Baolin Li, Wencong Lai, Zengqi Zhao, Tingting Hao, Zhiwei Chen, Jianlong Du, Yueru Li, Kangsen Mai, Qinghui Ai   +11 more
wiley   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Does intensive glycaemic control promote healing in diabetic foot ulcers? – a feasibility study

BMJ Open, 2020
Introduction One in four diabetes patients will develop a foot ulcer over their lifetime. The role of glycaemic control in the healing of foot ulcers in diabetes patients is not supported by randomised controlled trial (RCT) data.Objectives To determine ...
Ajith Dissanayake, Alain C Vandal, Veronica Boyle, Diane Park, Bobbie Milne, Roger Grech, Anthony Ng   +6 more
doaj   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

Research progress on assessment and nursing intervention of diabetic foot ulcer wound

Huli yanjiu, 2018
This article reviewed the assessment status quo of diabetic foot ulcer wound from medical staff and patients' cognition of diabetic foot ulcer,wound evaluation methods,and assessment tools.It analyzed the existing problems of diabetic foot ulcer wound ...
李梦圆, 喻姣花
doaj  

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source

Serum Homocysteine Values are Associated with Diabetic Foot Ulcer

Endocrinology Research and Practice, 2011
Background: Diabetic foot ulcers and lower extremity amputations are leading causes of mortality and morbidity in diabetic patients. Diabetic neuropathy and peripheral vascular diseases are major reasons for the development of diabetic foot ulcer.
Mehmet Erdoğan, Soner Solmaz, Abdullah Canataroğlu, Mustafa Kulaksızoğlu   +3 more
doaj   +2 more sources

Nano‐Backpack Engineered Probiotics with Reactive Oxygen Species–Responsive Tungsten Release for Synergistic Therapy of Inflammatory Bowel Disease

Advanced Science, EarlyView.
An integrated probiotic system is engineered to execute a programmed therapeutic cascade against inflammatory bowel disease. Upon pathological signals, the system sequentially performs ROS scavenging, tungsten release, and selective pathogen suppression, thereby breaking the oxidative stress–dysbiosis cycle to remodel gut microbiota and reinforce ...
Yang Yang, Liucan Wang, Guoqing Chen, Yuanling Zhang, Jiarui Shi, Wenzhe Fan, Min Yu, Jixi Zhang, Hua Yang   +8 more
wiley   +1 more source

Diabetes Foot Ulcer Risk - A Public Health Concern in Rural Pondicherry!!

National Journal of Community Medicine, 2018
Background: The risk of diabetes related complications is increas- ing with the increase in number of diabetes in rural population. Diabetes foot ulcer is a preventable complication of diabetes. Objective: To assess the diabetes foot ulcer risk among
Bijaya N Naik, Manikandan Srinivasan, Mahendra M Reddy, Srikanta Kanungo, Sonali Sarkar, Sitanshu S Kar   +5 more
doaj