Results 1 to 10 of about 211,756 (347)
Pathogens, 2021 In recent years, the scientific community has focused on the development of new antibiotics to address the difficulties linked to biofilm-forming microorganisms and drug-resistant infections.
Emilia Galdiero +8 more
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The International Review of Research in Open and Distributed Learning, 2012 <p>It is ironic that the management of education has become more closed while learning has become more open, particularly over the past 10-20 years. The curriculum has become more instrumental, predictive, standardized, and micro-managed in the belief that this supports employability as well as the management of educational processes, resources ...
Williams, Roy +2 more
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Bio-Protocol, 2020 DNA footprinting is a classic technique to investigate protein-DNA interactions. However, traditional footprinting protocols can be unsuccessful or difficult to interpret if the binding of the protein to the DNA is weak, the protein has a fast off-rate ...
Meng-Lun Hsieh +3 more
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Cell Proteomic Footprinting: Advances in the Quality of Cellular and Cell-Derived Cancer Vaccines
Pharmaceutics, 2023 In omics sciences, many compounds are measured simultaneously in a sample in a single run. Such analytical performance opens up prospects for improving cellular cancer vaccines and other cell-based immunotherapeutics. This article provides an overview of
Petr G. Lokhov +4 more
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HIV-1 Integrase-DNA Recognition Mechanisms
Viruses, 2009 Integration of a reverse transcribed DNA copy of the HIV viral genome into the host chromosome is essential for virus replication. This process is catalyzed by the virally encoded protein integrase. The catalytic activities, which involve DNA cutting and
Mamuka Kvaratskhelia +5 more
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Toxics, 2022 For over a decade, New Approach Methodologies (NAMs) such as structure-activity/read-across, -omics technologies, and Adverse Outcome Pathway (AOP), have been considered within regulatory communities as alternative sources of chemical and biological ...
Jason C. Lambert
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Antibodies, 2022 Commercial monoclonal antibodies are growing and important components of modern therapies against a multitude of human diseases. Well-known high-resolution structural methods such as protein crystallography are often used to characterize antibody ...
Corie Y. Ralston, Joshua S. Sharp
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Comparative evaluation of DNase-seq footprint identification strategies
Frontiers in Genetics, 2014 DNase I is an enzyme preferentially cleaving DNA in highly accessible regions. Recently, Next-Generation Sequencing has been applied to DNase I assays (DNase-seq) to obtain genome-wide maps of these accessible chromatin regions.With high-depth sequencing,
Iros eBarozzi +2 more
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Molecular Plant-Microbe Interactions, 2000 The phaseolotoxin-resistant ornithine carbamoyltransferase (ROCT) and phaseolotoxin are produced by Pseudo-monas syringae pv. phaseolicola at 18°C but not at 28°C.
Karla B. Rowley +2 more
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An automated liquid jet for fluorescence dosimetry and microsecond radiolytic labeling of proteins
Communications Biology, 2022 A high-speed liquid jet delivery system improves the X-ray footprinting and mass spectrometry method to label proteins for structural studies.
Matthew Rosi +16 more
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