Results 81 to 90 of about 7,852,123 (299)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Determination of the angles of pressure in the system of limitation by optimisation of linkages [PDF]

Transport, 2006
In the present paper a method of analytical determination of reactions and angles of pressure is considered with the four-bar linkage as an example. The determined sequence for the expression of acceleration of the points and angle acceleration of the ...
A. Demokritova, V. Demokritov
doaj  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Propulsive Power in Cross-Country Skiing: Application and Limitations of a Novel Wearable Sensor-Based Method During Roller Skiing

Frontiers in Physiology, 2018
Cross-country skiing is an endurance sport that requires extremely high maximal aerobic power. Due to downhill sections where the athletes can recover, skiers must also have the ability to perform repeated efforts where metabolic power substantially ...
Øyvind Gløersen, Øyvind Gløersen, Thomas Losnegard, Anders Malthe-Sørenssen, Anders Malthe-Sørenssen, Dag Kristian Dysthe, Matthias Gilgien, Matthias Gilgien   +7 more
doaj   +1 more source

Inadmissible Forcing

Advances in Mathematics, 1987
The notion of a partial recursive function has been generalized by Normann and Moschovakis so that arbitrary sets are allowed as arguments. The authors use a forcing technique over transitive, recursively closed sets to prove the following: if L(\(\kappa)\) is countable, recursively closed, non \(\Sigma_ 1\)-admissible and the greatest cardinal of L(\(\
Sacks, G.E, Slaman, T.A
openaire   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Mechanical and mathematical research of local deformations of a steel roller shell with a variable geometry of contact surface

Production Engineering Archives, 2019
The article is devoted to solving the fundamental and applied problem of nonlinear structural mechanics of machines by introducing into the drum two additional stop cylinders with supporting rollers at the end and adjustable length, providing a given ...
Doudkin Mikhail, Kim Alina, Sakimov Murat   +2 more
doaj   +1 more source

Roughness correction to the Casimir force : Beyond the Proximity Force Approximation

, 2004
We calculate the roughness correction to the Casimir effect in the parallel plates geometry for metallic plates described by the plasma model. The calculation is perturbative in the roughness amplitude with arbitrary values for the plasma wavelength, the
A Lambrecht, Casimir H. B. G., Lambrecht A., Maia Neto P. A., P. A. Maia Neto, S Reynaud   +5 more
core   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source