Results 161 to 170 of about 124,269 (264)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Cooperative control of a DNA origami force sensor. [PDF]

Sci Rep
Robbins A, Hildebolt H, Neuhoff M, Beshay P, Winter JO, Castro CE, Bundschuh R, Poirier MG.   +7 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

A nanonewton force sensor using a U-shape tapered microfiber interferometer. [PDF]

Sci Adv
Chen L, Liu B, Markwell C, Liu J, He XD, Ghassemlooy Z, Torun H, Fu YQ, Yuan J, Liu Q, Farrell G, Wu Q.   +11 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Flexible Force Sensor Based on a PVA/AgNWs Nanocomposite and Cellulose Acetate. [PDF]

Sensors (Basel)
Castillo-López DN, Gómez-Pavón LDC, Gutíerrez-Nava A, Zaca-Morán P, Arriaga-Arriaga CA, Muñoz-Pacheco JM, Luis-Ramos A.   +6 more
europepmc   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

Molecular Compressive Force Sensor for Mapping Forces at the Cell-Substrate Interface. [PDF]

J Am Chem Soc
Al Abdullatif S, Narum S, Hu Y, Rogers J, Fitzgerald R, Salaita K.   +5 more
europepmc   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

A force sensor improves trainee technique for rigid endoscopy. [PDF]

J Laryngol Otol
Bola S, Shrivastava MK, Brown J, Cherko M, Emmanouil B.   +4 more
europepmc   +1 more source