Results 81 to 90 of about 569,034 (301)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Oscillistor-based force sensor

Journal of Physics: Conference Series, 2020
Abstract The development of an oscillistor based force sensor with a frequency output is introduced. Sensor can operate in a wide temperature range from room to cryogenic. Experimental studies were carried out at temperatures of 77 and 295 K. Force sensor sensitivity is 0.9 kHz/N in the force range (0–10)N at temperature 295K. A decrease
Alexander I. Cheredov, Andrey V. Shchelkanov   +1 more
openaire   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Measurement of the Switching Force without Force Sensor

Advances in Electrical and Electronic Engineering, 2004
At the railways, some parts of the a high speed corridor are being finished at present. In these corridors, trains can reach the speed of up to 160 km per hour. Consequently, the demand on switch point machine computer diagnostics has arisen.
Bohumil Skala
doaj  

A Micro-Fabricated Force Sensor Using an All Thin Film Piezoelectric Active Sensor

Sensors, 2014
The ability to measure pressure and force is essential in biomedical applications such as minimally invasive surgery (MIS) and palpation for detecting cancer cysts.
Junwoo Lee, Wook Choi, Yong Kyoung Yoo, Kyo Seon Hwang, Sang-Myung Lee, Sungchul Kang, Jinseok Kim, Jeong Hoon Lee   +7 more
doaj   +1 more source

Universal Vectorial and Ultrasensitive Nanomechanical Force Field Sensor

, 2016
Miniaturization of force probes into nanomechanical oscillators enables ultrasensitive investigations of forces on dimensions smaller than their characteristic length scale.
A Cleland, A Gloppe, A Nigues, A Siria, AW Rodriguez, B Derjaguin, B Pigeau, BD Terris, Benjamin Besga, Benjamin Pigeau, CL Degen, CM Mate, D Cadeddu, D Ramos, D Rugar, E Gil-Santos, E Sage, F Chen, G Binnig, I Yeo, J Chaste, J Gieseler, J Moser, J Nichol, JM Nichol, K Jensen, K Karrai, K Schwab, KL Ekinci, Laure Mercier de Lépinay, M Ganzhorn, M Montinaro, M Pinard, MS Hanay, MS Rodrigues, O Arcizet, Olivier Arcizet, P Bushev, P Ovartchaiyapong, P Peddibhotla, Pascal Vincent, Philippe Poncharal, R Garcia, RO Behunin, S Kuehn, T Barois, T Faust, T Li, Y Martin   +48 more
core   +3 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Draft Sensor Loading Analysis

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2014
This article deals with loading analysis of draft sensor which is used in nowadays tractor as standard. Directional sensitivity and response to the loading force of draft sensor behavior are the main goal of this work.
Dušan Slimařík, Pavel Sedlák, Petr Dostál   +2 more
doaj   +1 more source