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Force Spectroscopy in Studying Infection [PDF]
, 2016 Biophysical force spectroscopy tools - for example optical tweezers, magnetic tweezers, atomic force microscopy, - have been used to study elastic, mechanical, conformational and dynamic properties of single biological specimens from single proteins to whole cells to reveal information not accessible by ensemble average methods such as X-ray ...
Leake, Mark Christian, Zhou, Zhaokun
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Relevance of Host Cell Surface Glycan Structure for Cell Specificity of Influenza A Viruses
Viruses, 2023 Influenza A viruses (IAVs) initiate infection via binding of the viral hemagglutinin (HA) to sialylated glycans on host cells. HA’s receptor specificity towards individual glycans is well studied and clearly critical for virus infection, but the ...
Markus Kastner +13 more
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Theory of rapid force spectroscopy [PDF]
Nature Communications, 2014 AbstractIn dynamic force spectroscopy, single (bio-)molecular bonds are actively broken to assess their range and strength. At low loading rates, the experimentally measured statistical distributions of rupture forces can be analysed using Kramers’ theory of spontaneous unbinding.
Bullerjahn, Jakob T. +2 more
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Beilstein Journal of Nanotechnology, 2012 Noncontact atomic force microscopy (NC-AFM) is being increasingly used to measure the interaction force between an atomically sharp probe tip and surfaces of interest, as a function of the three spatial dimensions, with picometer and piconewton accuracy.
Mehmet Z. Baykara +5 more
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Force Mapping Study of Actinoporin Effect in Membranes Presenting Phase Domains
Toxins, 2021 Equinatoxin II (EqtII) and Fragaceatoxin C (FraC) are pore-forming toxins (PFTs) from the actinoporin family that have enhanced membrane affinity in the presence of sphingomyelin (SM) and phase coexistence in the membrane.
Katia Cosentino +5 more
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Automated Dielectrophoretic Tweezers-Based Force Spectroscopy System in a Microfluidic Device
Sensors, 2017 We reported an automated dielectrophoretic (DEP) tweezers-based force spectroscopy system to examine intermolecular weak binding interactions, which consists of three components: (1) interdigitated electrodes and micro-sized polystyrene particles used as
Min Hyung Kim +11 more
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Diamond Colloidal Probe Force Spectroscopy [PDF]
Analytical Chemistry, 2019 Diamond is a highly attractive coating material as it is characterized by a wide optical transparency window, a high thermal conductivity, and an extraordinary robustness due to its mechanical properties and its chemical inertness. In particular, the latter has aroused a great deal of interest for scanning probe microscopy applications in recent years.
Peter Knittel +2 more
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Beilstein Journal of Nanotechnology, 2014 Unspecific adhesion of bacteria is usually the first step in the formation of biofilms on abiotic surfaces, yet it is unclear up to now which forces are governing this process.
Nicolas Thewes +6 more
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Analysis of membrane structure of the inner ear motor protein prestin by force spectroscopy
Journal of Biomechanical Science and Engineering, 2021 The high sensitivity of mammalian hearing is achieved by cochlear amplification. The basis of this amplification is the motility of outer hair cells (OHCs), which are sensory cells in the inner ear.
Michio MURAKOSHI, Hiroshi WADA
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Force Spectroscopy of Single Biomolecules [PDF]
ChemPhysChem, 2002 Many processes in the body are effected and regulated by highly specialized protein molecules: These molecules certainly deserve the name "biochemical nanomachines". Recent progress in single-molecule experiments and corresponding simulations with supercomputers enable us to watch these "nanomachines" at work, revealing a host of astounding mechanisms.
Rief, M., Grubmueller, H.
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