Results 121 to 130 of about 15,565,753 (347)

The heterogeneity of monocyte-derived macrophages in MASH pathogenesis

Cell Communication and Signaling
Metabolic dysfunction-associated fatty liver disease (MAFLD) is the leading global cause of chronic liver disease. Its more severe inflammatory form, metabolic dysfunction-associated steatohepatitis (MASH), often progresses to cirrhosis and ...
Miao Zhang, Erzhuo Xia, Chongxiao Li, Shuoyi Ma, Fangfang Yang, Siyuan Tian, Xia Zhou, Xiaohong Zheng, Bo Li, Hui Yang, Jingbo Wang, Ying Han   +11 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

RSK4 promotes the metastasis of clear cell renal cell carcinoma by activating RUNX1-mediated angiogenesis

Cancer Biology & Therapy
Ribosomal S6 protein kinase 4 (RSK4), a member of the serine‒threonine kinase family, plays a vital role in the Ras‒MAPK pathway. This kinase is responsible for managing several cellular activities, including cell growth, proliferation, survival, and ...
Jing Ma, Yanru Yang, Kaijing Wang, Jin Liu, Junyi Feng, Gongcheng Wang, Shuangping Guo, Linni Fan   +7 more
doaj   +1 more source

Helices 2 and 3 are the initiation sites in the PrPc -> PrPsc transition

, 2012
It is established that prion protein is the sole causative agent in a number of diseases in humans and animals. However, the nature of conformational changes that the normal cellular form PrPC undergoes in the conversion process to a self-replicating ...
Chen, Jie, Thirumalai, Devarajan
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Glutamine synthetase shields triple-negative breast cancer cells from ferroptosis in metastasis triggered by glutamine deprivation

Breast Cancer Research
Background Epithelial-mesenchymal transition (EMT) in cancer cell metastasis involves complicated metabolic plasticity to survive the highly challenging environment, such as oxidative stress, after subsequent circulation in the bloodstream.
Zhaoting Yang, Xinyu Lian, Yuan Luo, Qiao Ye, Guangjin Guo, Guoquan Liu   +5 more
doaj   +1 more source

A Modified pBRDF Model Considering the Influence of Relative Azimuth Angle for Coating Targets

IEEE Photonics Journal
The key to the researches on the polarization characteristics of targets lies in the precise establishment of the polarization model—the polarized bidirectional reflectance distribution function (pBRDF).
Zhiyong Yang, Yihui Zhang, Zhili Zhang, Zhiwei Zhang, Shun Li, Xiaowei Wang   +5 more
doaj   +1 more source

GEOECOLOGICAL DIAGNOSTICS OF THE REGIONS IN THE CENTRALBLACK SOIL REGION

Юг России: экология, развитие, 2019
Aim. The aim is geoecological diagnostics of regions of the Central Black Soil Region on the basis of which the areas with different degree of tension of a technogenic and medicoecological situation have been revealed.
S. A. Kurolap, N. V. Yakovenko, V. I. Fedotov, V. B. Mikhno, L. N. Kostyleva   +4 more
doaj   +1 more source

Nonlinear lattice model of viscoelastic Mode III fracture

, 2000
We study the effect of general nonlinear force laws in viscoelastic lattice models of fracture, focusing on the existence and stability of steady-state Mode III cracks.
A. Paskin, D. A. Kessler, D. A. Kessler, D. A. Kessler, D. A. Kessler, D. Holland, David A. Kessler, E. Brener, E. Sharon, E. Sharon, Herbert Levine, J. A. Hauch, J. Fineberg, J. Fineberg, J. Fineberg, J. S. Langer, L. I. Slepyan, M. Marder, M. Marder, O. Pla, P. Gumbsch, S. J. Zhou, Sh. A. Kulamekhtova   +22 more
core   +1 more source

Awakening: Predicting external stimulation to force transitions between different brain states

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance We describe a quantitative and robust definition of a brain state as an ensemble of “metastable substates,” each with a probabilistic stability and occurrence frequency.
G. Deco, Josephine Cruzat, J. Cabral, E. Tagliazucchi, H. Laufs, N. Logothetis, M. Kringelbach   +6 more
semanticscholar   +1 more source