Results 101 to 110 of about 175,963,440 (255)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
An Investigation on Shape Morphing by Modulus Variation: Forward Approach
Journal of Engineering, 2014 Structural shape deformation, in its conventional way, includes applying forces to a fixed-compliance structure to deform it to certain shapes. Rather than addressing shape control in the established way (applying forces to elastically or plastically ...
Amin Mohaghegh Motlagh, William W. Clark
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
The Driving Forces Of Land Change In The Northern Piedmont Of The United States [PDF]
, 2012 Driving forces facilitate or inhibit land-use / land-cover change. Human driving forces include political, economic, cultural, and social attributes that often change across time and space.
Sayler, Kristi L. +4 more
core
Spatial patterns and driving forces of land use change in China during the early 21st century
, 2010 Land use and land cover change as the core of coupled human-environment systems has become a potential field of land change science (LCS) in the study of global environmental change.
Wu Shixin +11 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Analysis on Land Use Change in Xinxiang City
Shuitu baochi yanjiu, 2008 Land use change can reflect the influence of human activity on nature.Based on the land use statistic data in 1996-2003,this article deeply analyzed the dynamic change on land use and its driving forces in Xinxiang city.The results show that constructive
WANG An-zhou +3 more
doaj
CHANGE MANAGEMENT IN NATIONAL SECURITY INSTITUTIONS [PDF]
Management & Marketing, 2012 Traditional association with defense military security no longer meets the new security environment indicators of national and international scope of the concept extending far beyond military matters to non-military aspects.
Laurentiu BARCAN
doaj
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source