Results 121 to 130 of about 1,369,551 (340)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Research and Practice of the Management and Protection Mode of Yantai Mountain National Marine Park

open access: yesHaiyang Kaifa yu guanli
The National Marine Park is an effective mean of protecting and managing marine resources in China. However, deficiencies in management organizational capacity, social engagement capacity, and system-based management service measures in the Yantai ...
LI Feng   +7 more
doaj  

Study on the characteristics of interannual dynamic variations in groundwater levels in the Dianchi lake basin

open access: yesCarsologica Sinica
Between 1980 and 2020, with the continuous development of the social economy and the expansion of urban areas, the urban underground engineering in the Dianchi lake basin, also known as the Kunming basin, became increasingly dense.
Junrong ZHOU   +6 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

2017 Alaska's Construction Spending Forecast [PDF]

open access: yes, 2017
The total value of construction spending “on the street” in Alaska in 2017 will be $6.5 billion, down 10% from 2016.1, 2,3 Oil and gas sector spending will fall 15% to $2.4 billion, from $2.9 billion last year. All other construction spending will be $4.
Cravez, Pamela, Goldsmith, Oliver Scott
core  

Earthquake Forecast via Neutrino Tomography

open access: yes, 2011
We discuss the possibility of forecasting earthquakes by means of (anti)neutrino tomography. Antineutrinos emitted from reactors are used as a probe. As the antineutrinos traverse through a region prone to earthquakes, observable variations in the matter
Akhmedov E K   +19 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

open access: yesFEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Detecting and Predicting Forecast Breakdowns [PDF]

open access: yes
We propose a theoretical framework for assessing whether a forecast model estimated over one period can provide good forecasts over a subsequent period.
Giacomini, Raffaella, Rossi, Barbara
core  

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