Results 141 to 150 of about 449,929 (285)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

A real-time forecasting framework for emerging infectious diseases affecting animal populations. [PDF]

PLoS Comput Biol
Theng M, Lee S, Breed AC, Roche S, Sellens E, Fraser C, Wood K, Jewell CP, Stevenson MA, Baker C, Firestone SM.   +10 more
europepmc   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Socio-economic value of data-driven eruption forecasts to balance false alarms against catastrophic loss. [PDF]

Nat Commun
Ardid A, Dempsey D, McDonald G, Cronin S.   +3 more
europepmc   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Insights on United States cumulative measles cases during the 2026 outbreak using ARIMA and generalized linear models. [PDF]

Front Epidemiol
Gondim A, Chukwu CW, Agusto FB, Ologbonyo J.   +3 more
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Probabilistic forecasting of under-five mortality in Uganda: implications for monitoring SDG 3.2. [PDF]

Front Public Health
Gaston RT, Ramroop S, Habyarimana F.
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Dynamics and Forecasting of Emergency Department Presentations: An Integrative Approach Based on Statistical Analysis and Time-Series Models. [PDF]

Healthcare (Basel)
Sas LM, Popescu AC, Ducu VI, Popescu L, Buligiu I, Mihai LS, Cojocaru MD, Sas TN.   +7 more
europepmc   +1 more source