Results 161 to 170 of about 130,658 (268)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

dAMN: a genome-scale neural-mechanistic hybrid model to predict bacterial growth dynamics. [PDF]

Bioinformatics
Faulon JL, Dursoniah D, Ahavi P, Raynal A, Asin-Garcia E.   +4 more
europepmc   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Advancing operational global aerosol forecasting with machine learning. [PDF]

Nature
Gui K, Zhang X, Che H, Che H, Li L, Zheng Y, An L, Miao Y, Zhao H, Dubovik O, Holben B, Wang J, Gupta P, Lind ES, Toledano C, Wang H, Wang Z, Wang Y, Huang X, Dai K, Xia X, Xu X, Zhang X.   +22 more
europepmc   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Granulocyte and monocyte adsorption therapy in sepsis: a propensity score-matched analysis. [PDF]

J Intensive Care
Hisamune R, Yamakawa K, Nakamura T, Doi K, Takahashi G, Moriyama K, Ishihara T, Nishida O.   +7 more
europepmc   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

A Regionally Determined Climate-Informed West Nile Virus Forecast Technique. [PDF]

Geohealth
Harp RD, Holcomb KM, Benjamin SG, Green BW, Jones H, Johansson MA.   +5 more
europepmc   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Increasing landslide susceptibility and intensity under climate change for Aotearoa New Zealand. [PDF]

Sci Rep
Dreyer L, Robinson TR, Katurji M, Leith K, Williams JH.   +4 more
europepmc   +1 more source