Results 51 to 60 of about 367,044 (300)

Global seasonal prediction of fire danger

Scientific Data
The European Centre for Medium range weather forecast (ECMWF) on behalf of the Copernicus Emergency Management Service (CEMS) has recently widened the fire danger data offering in the Climate Data Store (CDS) to include a set of fire danger forecasts ...
Francesca Di Giuseppe, Claudia Vitolo, Christopher Barnard, Giorgio Libertá, Pedro Maciel, Jesus San-Miguel-Ayanz, Sebastien Villaume, Fredrik Wetterhall   +7 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Performance Forecasting

, 2009
Schon seit mehreren Jahrzehnten wird bei meisten Unternehmen Performance Tuning von Rechnersystemen betrieben. Dieses Thema wurde wie von der Seite der Unternehmen als auch von der Wissenschaft mittlerweile in zahlreichen unterschiedlichen Aspekten erforscht und ausgearbeitet.
Tropmann-Frick, Marina, Thalheim, Bernhard, Korff, Ralf   +2 more
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Predicting the current fishable habitat distribution of Antarctic toothfish (Dissostichus mawsoni) and its shift in the future under climate change in the Southern Ocean [PDF]

PeerJ
Global warming continues to exert unprecedented impacts on marine habitats. Species distribution models (SDMs) are proven powerful in predicting habitat distribution for marine demersal species under climate change impacts.
Jie Liu, Ancheng Zhu, Xitao Wang, Xiangjun Zhou, Lu Chen   +4 more
doaj   +2 more sources

Forecasting volatility [PDF]

Journal of Futures Markets, 1999
The forecasting ability of the most popular volatility forecasting models is examined and an alternative model developed. Existing models are compared in terms of four attributes: (1) the relative weighting of recent versus older observations, (2) the estimation criterion, (3) the trade-off in terms of out-of-sample forecasting error between simple and
Ederington, Louis H., Guan, Wei
openaire   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

ESA-ECMWF Report on recent progress and research directions in machine learning for Earth System observation and prediction

npj Climate and Atmospheric Science, 2022
This paper provides a short summary of the outcomes of the workshop on Machine Learning (ML) for Earth System Observation and Prediction (ESOP / ML4ESOP) organised by the European Space Agency (ESA) and the European Centre for Medium-Range Weather ...
Rochelle Schneider, Massimo Bonavita, Alan Geer, Rossella Arcucci, Peter Dueben, Claudia Vitolo, Bertrand Le Saux, Begüm Demir, Pierre-Philippe Mathieu   +8 more
doaj   +1 more source

Defensive forecasting [PDF]

CoRR, 2005
We consider how to make probability forecasts of binary labels. Our main mathematical result is that for any continuous gambling strategy used for detecting disagreement between the forecasts and the actual labels, there exists a forecasting strategy whose forecasts are ideal as far as this gambling strategy is concerned.
Vovk, Vladimir, Takemura, Akimichi, Shafer, Glenn   +2 more
openaire   +10 more sources