Results 111 to 120 of about 524,481 (298)

AutoML-Based Prediction of Unconfined Compressive Strength of Stabilized Soils: A Multi-Dataset Evaluation on Worldwide Experimental Data

Forecasting
Unconfined Compressive Strength (UCS) of stabilized soils is commonly used for evaluating the effectiveness of soil improvement techniques. Achieving target UCS values through conventional trial-and-error approaches requires extensive laboratory ...
Romulo Murucci Oliveira, Deivid Campos, Katia Vanessa Bicalho, Bruno da S. Macêdo, Matteo Bodini, Camila Martins Saporetti, Leonardo Goliatt   +6 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Shadows of Demand: Uncovering Early Warning Signals of Private Consumption Declines in Romania

Forecasting
Policymakers in small open economies need reliable signals of incipient private consumption downturns, yet traditional indicators are revised, noisy, and often arrive too late.
Laurențiu-Gabriel Frâncu, Alexandra Constantin, Maxim Cetulean, Diana Andreia Hristache, Monica Maria Dobrescu, Raluca Andreea Popa, Alexandra-Ioana Murariu, Roxana Lucia Ungureanu   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Forecasting the UK Unemployment Rate: Model Comparisons [PDF]

This paper compares the out-of-sample forecasting accuracy of time series models using the Root Mean Square, Mean Absolute and Mean Absolute Percent Errors.
Floros, Ch.
core  

Forecasting

, 2020
From the University of Michigan Business Intelligence Community of Experts:ForecastingPresenter: Jeff Horon, Business Analyst, Medical School Grant Review & Analysis OfficeAbstract:Forecasting can enable better data-driven decisions.
Jeff Horon (8364345)
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source