Results 71 to 80 of about 146,575 (268)
Forecasting Convective Storms Trajectory and Intensity by Neural Networks
ForecastingConvective storms represent a dangerous atmospheric phenomenon, particularly for the heavy and concentrated precipitation they can trigger. Given their high velocity and variability, their prediction is challenging, though it is crucial to issue reliable
Niccolò Borghi +2 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
ForecastingEvaluation of water quality and accurate prediction of water pollution indicators are key components in water resource management and water pollution control.
Aleksandr N. Grekov +2 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Forecaster’s Dilemma: Extreme Events and Forecast Evaluation
Statistical Science, 2017 In public discussions of the quality of forecasts, attention typically focuses on the predictive performance in cases of extreme events. However, the restriction of conventional forecast evaluation methods to subsets of extreme observations has unexpected and undesired effects, and is bound to discredit skillful forecasts when the signal-to-noise ratio
Lerch, Sebastian +3 more
openaire +5 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
ForecastingAccurately predicting carbon trading price is challenging due to pronounced nonlinearity, non-stationarity, and sensitivity to diverse factors, including macroeconomic conditions, market sentiment, and climate policy.
Xu Wang +5 more
doaj +1 more source
International Journal of ForecastingForecasts are typically not produced in a vacuum but in a business context, where forecasts are generated on a regular basis and interact with each other. For decisions, it may be important that forecasts do not change arbitrarily, and are stable in some sense. However, this area has received only limited attention in the forecasting literature.
Rakshitha Godahewa +6 more
openaire +3 more sources