Results 141 to 150 of about 234,079 (317)

Analysis and Characterization of Kisspeptin and Its Analogues in Serum and Urine Samples by Liquid Chromatography–High‐Resolution Mass Spectrometry for Doping Control Purposes

open access: yesDrug Testing and Analysis, EarlyView.
Sensitive LC‐HRMS methods were established for the detection of kisspeptin and its analogues in serum and urine, alongside their analytical and metabolic characterization. Stability studies were conducted in serum, plasma, and urine, highlighting the importance of appropriate sample handling for reliable anti‐doping analysis.
Sophia Krombholz   +3 more
wiley   +1 more source

Segmental Hair Analysis of Diphenhydramine and Cyclizine Following a Single Dose

open access: yesDrug Testing and Analysis, EarlyView.
A single oral dose of diphenhydramine and cyclizine can be quantified in human head hair for a minimum of 5 months and, in certain cases, for up to 1 year following intake. Among 12 study participants, the measured concentrations ranged from 0 to 610 pg/mg within 1 year post‐intake.
Jan Bílek   +3 more
wiley   +1 more source

Data interpretation in forensic sediment and soil geochemistry

open access: yes, 2006
Automated geochemical techniques enable reproducible elemental assays of small quantity samples and have been used in recent years in many forensic criminal investigations in England and Wales.
Morgan, RM, Bull, PA
core  

Determination of THC and THC‐COOH in Dried Capillary Blood Spots and Comparison to Venous Blood of Recreational Cannabis Consumers in a Pilot Study

open access: yesDrug Testing and Analysis, EarlyView.
A new extraction method was developed and validated for the extraction of THC and THC‐COOH from capillary blood samples collected as dried blood spots. The extracts were analysed using HPLC–MS/MS resulting in high extraction efficiencies for both THC and THC‐COOH.
Matthias Bantle   +7 more
wiley   +1 more source

Forensic Computing Concepts - Introduction

open access: yes, 2010
Video lecture from a series on Forensic Computing Concepts delivered by Bob Shaw and Hatem Tammam. Running time approximately 47 minutes.
Robert Shaw, Staffordshire University
core  

Assessment of Abuse Potential‐Related Effects of Oral Dried Kratom Leaf Powder in Healthy Normal Participants Following Single and Multiple Daily Doses

open access: yesDrug Testing and Analysis, EarlyView.
In a randomized, double‐blind, placebo‐controlled study of oral dried kratom leaf powder in healthy kratom‐naive adults, no participants met the clinically meaningful opioid withdrawal threshold; abuse‐related treatment‐emergent adverse events occurred more frequently at higher doses but were generally mild and resolved without sequelae; and no serious
Marion Coe   +5 more
wiley   +1 more source

Comparison of Dried Blood Spot Sampling Methods for RNA‐Based Biomarker Measurement in Anti‐Doping

open access: yesDrug Testing and Analysis, EarlyView.
This study demonstrates that RNA‐based biomarkers of erythropoiesis, ALAS2 and CA1, can be reliably quantified across commonly used DBS sampling matrices, including venous and capillary blood spotted on cellulose cards and the Tasso‐M20 device. ABSTRACT Dried blood spot (DBS) sampling offers logistical advantages, but it remains unexplored whether ...
Jacob Bejder   +9 more
wiley   +1 more source

Elimination Profile of Deflazacort and Metabolites in Urine and Plasma Following Oral Administration: Relevance to Sports Drug Testing

open access: yesDrug Testing and Analysis, EarlyView.
Results confirm that the MRL of 30 ng/mL for 21‐desacetyl‐deflazacort together with a 3‐day washout period is an appropriated strategy to detect oral deflazacort administration in sport competition. ABSTRACT Deflazacort (DEF) is a glucocorticoid prohibited in sports competitions when orally administered.
Sergi Coll   +5 more
wiley   +1 more source

Investigation of the In Vitro and In Vivo Metabolism and μ‐Opioid Receptor Affinity of the Nitazene N‐Pyrrolidino Fluetonitazene

open access: yesDrug Testing and Analysis, EarlyView.
Eight metabolites for N‐pyrrolidino fluetonitazene were identified in vitro, three of which (M2, M6 and M8) were present in an authentic urine sample. M2 was the most abundant in vivo metabolite and is a common marker metabolite of nitazepyne‐type substances.
Severin Zemp   +6 more
wiley   +1 more source

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