Results 41 to 50 of about 73,469 (269)

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Phylogenetic insights into the genetic legacies of Hungarian-speaking communities in the Carpathian Basin

Scientific Reports
This study focuses on exploring the uniparental genetic lineages of Hungarian-speaking minorities residing in rural villages of Baranja (Croatia) and the Zobor region (Slovakia).
Noémi Borbély, Dániel Dudás, Attila Tapasztó, Eszter Dudás-Boda, Veronika Csáky, Bea Szeifert, Balázs Gusztáv Mende, Balázs Egyed, Anna Szécsényi-Nagy, Horolma Pamjav   +9 more
doaj   +1 more source

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

Sex- and ALDH2-dependent differences in alcohol metabolism and psychomotor performance: a study in Han Chinese adults after binge drinking

Annals of Medicine
Background Psychomotor impairments due to alcohol consumption may lead to a series of negative consequences. However, the influence of sex and ALDH2 polymorphism on psychomotor dysfunction has not yet been investigated.Methods One-hundred and three ...
Yi Ye, Yidie Lin, Takeshi Haseba, Fan Chen, Fanlai Cui, Xiaoqin Yi, Weihao Fan, Gangqin Li   +7 more
doaj   +1 more source

Meeting of the ENFSI Textile and Hair Group (Zurich, Switzerland)

Теория и практика судебной экспертизы, 2018
The paper presents the outcomes of the 26th Meeting of the ENFSI Textile and Hair Expert Working Group and the Animal Hair Workshop held in Zurich (Switzerland) on June 11–15, 2018.
T. V. Perfilova, E. M. Nesterina
doaj   +1 more source

Gas Chromatography—Fourier Transform Infrared Spectroscopy for Unambiguous Determination of Illicit Drugs: A Proof of Concept

Frontiers in Chemistry, 2020
The increasing number of synthetic molecules constantly introduced into the illicit drug market poses a great demand in terms of separation and identification power of the analytical tools.
Tania M. G. Salerno, Paola Donato, Giampietro Frison, Luca Zamengo, Luigi Mondello, Luigi Mondello, Luigi Mondello, Luigi Mondello   +7 more
doaj   +1 more source

Forensic Analysis of Plug Computers [PDF]

, 2011
A plug computer is essentially a cross between an embedded computer and a traditional computer, and with many of the same capabilities. However, the architecture of a plug computer makes it difficult to apply commonly used digital forensic methods. This paper describes methods for extracting and analyzing digital evidence from plug computers.
Conrad, Scott, Dorn, Greg, Craiger, Philip   +2 more
openaire   +3 more sources

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Qualitative Analysis of Glass Microfragments Using the Combination of Laser-Induced Breakdown Spectroscopy and Refractive Index Data

Sensors, 2022
We have successfully demonstrated that although there are significant analytical challenges involved in the qualitative discrimination analysis of sub-mm sized (microfragment) glass samples, the task can be solved with very good accuracy and reliability ...
Dávid Jenő Palásti, Judit Kopniczky, Tamás Vörös, Anikó Metzinger, Gábor Galbács   +4 more
doaj   +1 more source

Astrocytic FDX1 Contributes to Copper Dyshomeostasis‐associated Synaptic Dysfunction in Depression and Is Modulated by Exercise

Advanced Science, EarlyView.
Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao, Rongji Hui, Zhibo Tang, Tao Feng, Zhihang Hu, Xiaoqing Zhang, Ping Jiang, Hui Zhao, Kwok‐Fai So, Tianyuan Luo, Yanzhou Chang, Lan Yan   +11 more
wiley   +1 more source