Results 131 to 140 of about 349,111 (293)
Ion Activation Methods for Top‐Down Proteomics
ABSTRACT Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top‐down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alternative RNA splicing events or the addition of post‐translational modifications. Tandem MS (i.e., MS/MS)
Jada N. Walker, Jennifer S. Brodbelt
wiley +1 more source
ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu +5 more
wiley +1 more source
Artificial Intelligence Revolution: The Need for a Regulatory and Governance Framework in Dentistry
Journal of Dental Education, EarlyView.
Ehsan Jozaghi
wiley +1 more source
Recent Advances in Top‐Down Proteomics for Single‐Cell Research
ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley +1 more source
Mass Spectrometry‐Based Extracellular Vesicle Proteomics for Biomarker Discovery
ABSTRACT Extracellular vesicle (EV) proteomics has emerged as a powerful platform for decoding intercellular communication and advancing biomarker discovery across human diseases. EVs carry proteins that reflect their cells of origin, offering a minimally invasive window into physiological and pathological processes.
Ya‐Juan Liu, Juan Peng, Chao Kang
wiley +1 more source
The article presents some preliminary results of medical and forensic analysis of traumatic injuries on the skulls from medieval burials found on the territory of Bolgar fortified settlement.
Albert I. Zholobov +2 more
doaj
ABSTRACT Wooden dentures represent a distinctive form of dental technology uniquely developed in Japan that is no longer in clinical use. Although Edo‐period (1603–1867) wooden dentures are presumed to have achieved sufficient precision, their morphological fit has not been quantitatively evaluated.
Kie Yoshida +3 more
wiley +1 more source
Abstract Background: Individuals with severe visual impairments frequently refrain from regular physical activity due to multiple barriers, including transportation difficulties, financial constraints, and limited availability of exercise programs tailored to their needs. These factors often contribute to a gradual decline in mobility and independence.
Luca Correale +7 more
wiley +1 more source
ABSTRACT Rationale In this study, we applied cross‐linking mass spectrometry (XL‐MS) to characterize the oligomeric states of a PGLa/magainin 2 mixture and gain insight into the heterodimerization previously suggested in the literature. Both peptides have shown a synergistic enhancement of activity when tested in antimicrobial assays; however, the ...
Emilie Hirschler +7 more
wiley +1 more source
Atypical localized Mongolian spots in dark pigmented skin - a challenge for forensic medical examination. [PDF]
Schlepper S +3 more
europepmc +1 more source

