Results 201 to 210 of about 380,766 (261)

Further Investigation Into an Environmental Source for Aminorex

Drug Testing and Analysis, EarlyView.
The results provide evidence that resedine is an intermediary compound between barbarin and aminorex in horses and that resedine can be used as a biomarker to eliminate the reporting of aminorex positives originating from the ingestion of plants from the Brassicaceae family.
Lydia Brooks, Michael Ryan, Erin McCosham, Devan Loganathan   +3 more
wiley   +1 more source

Rapid and Effective Determination of Ethyl Glucuronide in Hair by Micro Extraction by Packed Sorbent (MEPS) and LC‐MS/MS

Drug Testing and Analysis, EarlyView.
The development and validation of a MEPS method for the purification of hair extract for the EtG determination and quantification in the keratin matrix is the main focus of this study. The method is fast and effective and, as a miniaturised technique, requires only small amounts of solvent.
Sara Odoardi, Serena Mestria, Valeria Valentini, Giulia Biosa, Sabina Strano Rossi   +4 more
wiley   +1 more source

Associations Between Self‐Reported Cocaine Use Patterns and Cocaine and Its Metabolites in Hair: Implications for Clinical and Forensic Practices

Drug Testing and Analysis, EarlyView.
This study demonstrates that concentrations of cocaine and its main metabolites in hair reliably predict an individual's actual intensity of cocaine use and effectively differentiate between dependent and non‐dependent users. ABSTRACT In forensic toxicology, it has been debated if hair testing allows an estimation of the intensity of cocaine use—an ...
Simon Grison, Lydia Johnson‐Ferguson, Matthias Vonmoos, Markus R. Baumgartner, Boris B. Quednow   +4 more
wiley   +1 more source

β‐Hydroxy β‐Methyl Butyric Acid (HMB) and Its Potential Doping Relevance: A Pilot Study on Its Urinary Excretion Profile

Drug Testing and Analysis, EarlyView.
β‐hydroxy β‐methyl butyric acid (HMB), either as the free acid or in the form of its calcium salt, is a component of several dietary supplements marketed to enhance sports performance. We investigated the urinary excretion profile of HMB, also assessing the endogenous reference ranges of HMB in human urine samples from healthy volunteers (n = 20). Data
Cristian Camuto, Xavier de la Torre, Francesco Botrè, Fabio de Giorgio   +3 more
wiley   +1 more source

Determination of Hormonal Growth Promotants in Beef Using Liquid Chromatography–Tandem Mass Spectrometry

Drug Testing and Analysis, EarlyView.
An LC–MS/MS method was developed and validated to detect 12 synthetic or endogenous hormonal growth promotants commonly utilized in the livestock industry in the United States at low pg/mg concentrations. ABSTRACT Hormonal growth promotants (HGPs) are a class of pharmaceutical agents commonly administered to cattle in the United States to improve ...
Mary Mosburg, Yajing Li, Emily Helmes, Tara D. Falt, Josephine F. Trott, Gina Solomon, Russell C. Hovey, Benjamin C. Moeller   +7 more
wiley   +1 more source

Trends in the Detection of Erythropoietin Receptor Agonists (ERAs) in Anti‐Doping: An Analysis of Recent Adverse Analytical Findings (AAFs)

Drug Testing and Analysis, EarlyView.
Trends in adverse analytical findings (AAFs) for erythropoietin Receptor Agonist (ERAs) we examined to assess the impact of ERA testing and detection on athlete behavior. It was observed that the largest fraction of ERA AAFs occurs on the first sample ever taken from an athlete (43.2%), and that the ERA AAFs rates decline steadily as athletes continue ...
Tristan Equey, Julian Broséus, Norbert Baume, Reid Aikin   +3 more
wiley   +1 more source

Analytical and Pharmacological Characterization of 1‐(Furan‐2‐Carbonyl)‐LSD (1F‐LSD) and Comparison With 1‐(Thiophene‐2‐Carbonyl)‐LSD (1T‐LSD)

Drug Testing and Analysis, EarlyView.
The novel lysergamide 1‐(furan‐2‐carbonyl)‐LSD (1F‐LSD) was analytically characterized. 1F‐LSD showed LSD‐like activity in vivo similar to 1‐(thiophene‐2‐carbonyl)‐LSD (1T‐LSD) used for comparison. Administration studies in mice and LC–MS analysis revealed that 1F‐LSD served as a prodrug.
Simon D. Brandt, Pierce V. Kavanagh, Sarah Gare, Simon P. Elliott, Alexander Stratford, Adam L. Halberstadt   +5 more
wiley   +1 more source

UHPLC‐QTOFMS Urine Drug Screening With Dilute‐and‐Shoot Sample Preparation and Vacuum‐Insulated Probe‐Heated Electrospray Ionization

Drug Testing and Analysis, EarlyView.
The new ionization technique, vacuum‐insulated probe‐heated electrospray, allows for a simple dilute‐and‐shoot sample preparation to be used with liquid chromatography time‐of‐flight mass spectrometry in urine drug screening. Comparison with a method relying on solid‐phase extraction and conventional electrospray ionization shows improved performance ...
Mira Sundström, Pirkko Kriikku, Ilkka Ojanperä, Carsten Baessmann, Anna Pelander   +4 more
wiley   +1 more source

Annual Banned‐Substance Review 17th Edition—Analytical Approaches in Human Sports Drug Testing 2023/2024

Drug Testing and Analysis, EarlyView.
Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario  Thevis, Tiia  Kuuranne, Hans  Geyer   +2 more
wiley   +1 more source

Studies on the Stability and Microbial Biotransformation of Five Deschloroketamine Derivatives as Prerequisite for Wastewater‐Based Epidemiology Screening

Drug Testing and Analysis, EarlyView.
Microbial biotransformation and stability of deschloroketamine derivatives and their metabolites in WW by incubating parent compounds, rat urine, or rat feces showed that deschloroketamine parents and Phase I metabolite were still detectable and that Phase II metabolites decreased in peak areas.
Fabian Frankenfeld, Lea Wagmann, Markus R. Meyer   +2 more
wiley   +1 more source