Results 31 to 40 of about 14,364 (218)

Ageing related thyroid deficiency increases brain-targeted transport of liver-derived ApoE4-laden exosomes leading to cognitive impairment

Cell Death and Disease, 2022
Alzheimer’s disease (AD) is the prevalent cause of dementia in the ageing world population. Apolipoprotein E4 (ApoE4) allele is the key genetic risk factor for AD, although the mechanisms linking ApoE4 with neurocognitive impairments and aberrant ...
Manman Zhang, Wenliang Gong, Dianjun Zhang, Ming Ji, Binjie Chen, Beina Chen, Xinyu Li, Yuefei Zhou, Chengyi Dong, Gehua Wen, Xiaoni Zhan, Xiafang Wu, Lulu Cui, Yuliang Feng, Siman Wang, Huiya Yuan, Enyu Xu, Maosheng Xia, Alexei Verkhratsky, Baoman Li   +19 more
doaj   +1 more source

‘The System Can't Cope’: The Service System Response to Alcohol and Other Drug‐Facilitated Sexual Violence

Australian Journal of Social Issues, EarlyView.
ABSTRACT Alcohol and other drug‐facilitated sexual violence can have significant impacts on victim‐survivors, yet little is known about what support service providers offer them. To understand the experiences and perceptions of service providers, interviews with counsellors, health workers, forensic toxicologists and harm reduction workers were ...
Jessica Ison, Jacqui Theobald, Kirsty Forsdike, Ingrid Wilson, Elena Wilson, Leesa Hooker   +5 more
wiley   +1 more source

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Safety concerns reported by coroners following fentanyl patch fatalities in England, Wales and Northern Ireland between 1997 and 2024

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim To identify safety concerns reported by coroners following fentanyl patch‐related deaths in England, Wales and Northern Ireland, and determine differences in coronial reporting. Methods A systematic case series linking the National Programme on Substance Use Mortality (NPSUM) and the Preventable Deaths Tracker (PDT) (https ...
Eman Mshari, Caroline S. Copeland, Georgia C. Richards   +2 more
wiley   +1 more source

Annual Banned‐Substance Review 18th Edition—Analytical Approaches in Human Sports Drug Testing 2024/2025

Drug Testing and Analysis, EarlyView.
New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley   +1 more source

Forensic Toxicology Laboratory Guidelines: Analytical Method Validation (Version 2.0)

Arab Journal of Forensic Sciences & Forensic Medicine, 2020
Since postmortem forensic toxicology involves analyzing body fluids and organs from death cases, interpreting that information and studying the sudden unexpected and/or unexplained deaths as coroner’s cases or fall under the jurisdiction of the medical ...
Abdulsallam Bakdash, Jihad Al-Qudsi, Huda M. Hassan, Farouq Alzahrani, Sulaf Assi   +4 more
doaj   +1 more source

Evaluation of Therapeutic Opioids in Skin‐Derived Matrices (Sweat and Sebum) of Neonatal and Pediatric Patients and Their Role in Opioid Incorporation Into Hair

Drug Testing and Analysis, EarlyView.
Concentration ranges, dose–concentration relationships, and metabolite‐to‐parent drug ratios of therapeutic opioids were evaluated in hair and skin swab samples of 150 pediatric patients. Skin‐derived matrices such as sweat or sebum were shown to contribute to analyte incorporation into hair in a systematic manner.
Max Polke, Florian Zapf, Julia T. Scherer, Clarissa D. Voegel, Tanja Restin, Marc W. Schmid, Thomas Kraemer, Tina M. Binz   +7 more
wiley   +1 more source

Identification of Metabolites of the Dietary Supplement Ingredient 5α‐Hydroxy‐Laxogenin

Drug Testing and Analysis, EarlyView.
The biotransformation of the dietary supplement ingredient 5α‐hydroxy‐laxogenin was investigated using human HepG2 cells, the rat and in silico using the online software Next‐gen E‐Resource for Drug Discovery (NERDD). We identified five metabolites generated by the human HepG2 cells of which three and an additional mono‐hydroxylated metabolite were ...
Daniel Derwand, Oliver Zierau, Detlef Thieme, Annekathrin Martina Keiler   +3 more
wiley   +1 more source

Practice and Reflection on Forensic Toxicology from the Perspective of Evidence Reliability

Fayixue Zazhi
Improving the reliability of forensic toxicology identification results, the sufficiency of evidentiary information, and the admissibility of evidence is an essential requirement for the disciplinary, technological, and evidential attributes of forensic ...
SHEN Min
doaj   +1 more source

The neuroprotective mechanism of lithium after ischaemic stroke

Communications Biology, 2022
Using the MCAO stroke mouse model, Chen et al. identify pathways that underlie the neuroprotective properties of lithium by using inhibitors of AKT/GSK3β/β-catenin and AKT/FoxO3a/β-catenin signaling. They report that the inhibitors reverse the protective
Beina Chen, Manman Zhang, Ming Ji, Dianjun Zhang, Binjie Chen, Wenliang Gong, Xinyu Li, Yuefei Zhou, Chengyi Dong, Gehua Wen, Xiaoni Zhan, Xiafang Wu, Huiya Yuan, Enyu Xu, Maosheng Xia, Alexei Verkhratsky, Baoman Li   +16 more
doaj   +1 more source