Results 1 to 10 of about 44,777 (187)

Acellular foreskin dermal matrix is efficient in supporting the growth of urothelial cells derived from hypospadias patients [PDF]

Frontiers in Pediatrics
IntroductionHypospadias is a common congenital defect in males, with surgery remaining the primary treatment option. However, urethral reconstruction procedures often require additional tissue transplantation, which is limited by the availability of ...
Zhiqing Cao, Zhenwei Yang, Qunfang Ye, Juntan Xiong, Aozhou Zhu   +4 more
doaj   +2 more sources

Foreskin Reconstruction or Conventional Circumcision in Hypospadias: A Systematic Review and Meta-analysis

Journal of Indian Association of Pediatric Surgeons
Hypospadias is a common congenital anomaly of the male genitalia requiring surgical correction. During hypospadias repair, there are two broad approaches to deal with prepuce-foreskin reconstruction (FR) and conventional circumcision (CC).
Nitinkumar Borkar, Charu Sharma, Kanishka Das, Vijayendra Kumar, Mustafa Azizoglu, Purva Bani   +5 more
doaj   +2 more sources

An Effective Method for Decellularization of Human Foreskin: Implications for Skin Regeneration in Small Wounds [PDF]

Cell Journal, 2022
Objective: Acellular matrices of different allogeneic or xenogeneic origins are widely used as structural scaffolds in regenerative medicine. The main goal of this research was to optimize a method for decellularization of foreskin for skinregeneration ...
Shima Rahmati, Ali Jalili, Mehdi Dehkordi, Michelle Przedborski   +3 more
doaj   +1 more source

Immunohistological Analysis of Lichen Sclerosus of the Foreskin in Pediatric Age: Could It Be Considered a Premalignant Lesion?

Biomedicines, 2023
Background: A major worry of juvenile penile LS is potential malignant degeneration to spinocellular carcinoma (SCC) in adulthood. LS is characterized by increased CD8+ and CD57+ cells, dermal sclerosis, epidermal atrophy, and hyperkeratosis.
Salvatore Arena, Antonio Ieni, Monica Currò, Mario Vaccaro, Donatella Di Fabrizio, Fabiola Cassaro, Roberta Bonfiglio, Angela Simona Montalto, Giovanni Tuccari, Angela Alibrandi, Pietro Impellizzeri, Carmelo Romeo   +11 more
doaj   +1 more source

A pilot study to show that asymptomatic sexually transmitted infections alter the foreskin epithelial proteome

Frontiers in Microbiology, 2022
There is limited data on the role of asymptomatic STIs (aSTIs) on the risk of human immunodeficiency virus (HIV) acquisition in the male genital tract (MGT).
Nyaradzo T. L. Chigorimbo-Murefu, Matthys Potgieter, Matthys Potgieter, Sonwabile Dzanibe, Zikhona Gabazana, Gershom Buri, Aditya Chawla, Bokani Nleya, Abraham J. Olivier, Rushil Harryparsad, Bridget Calder, Shaun Garnett, Lungile Maziya, David A. Lewis, David A. Lewis, Heather Jaspan, Heather Jaspan, Heather Jaspan, Doug Wilson, Jo-Ann S. Passmore, Nicola Mulder, Jonathan Blackburn, Linda-Gail Bekker, Clive M. Gray, Clive M. Gray   +24 more
doaj   +1 more source

The inner foreskin of healthy males at risk of HIV infection harbors epithelial CD4+ CCR5+ cells and has features of an inflamed epidermal barrier. [PDF]

PLoS ONE, 2014
Male circumcision provides partial protection against multiple sexually transmitted infections (STIs), including HIV, but the mechanisms are not fully understood.
Maria P Lemos, Javier R Lama, Shelly T Karuna, Youyi Fong, Silvia M Montano, Carmela Ganoza, Raphael Gottardo, Jorge Sanchez, M Juliana McElrath   +8 more
doaj   +1 more source

In Vitro Cellular and Molecular Interplay between Human Foreskin-Derived Mesenchymal Stromal/Stem Cells and the Th17 Cell Pathway

Pharmaceutics, 2021
Foreskin, considered a biological waste material, has been shown to be a reservoir of therapeutic cells. The immunomodulatory properties of mesenchymal stromal/stem cells (MSCs) from the foreskin (FSK-MSCs) are being evaluated in cell-based therapy for ...
Mehdi Najar, Makram Merimi, Wissam H. Faour, Catherine A. Lombard, Douâa Moussa Agha, Yassine Ouhaddi, Etienne M. Sokal, Laurence Lagneaux, Hassan Fahmi   +8 more
doaj   +1 more source

No difference in keratin thickness between inner and outer foreskins from elective male circumcisions in Rakai, Uganda. [PDF]

PLoS ONE, 2012
It has been hypothesized that increased HIV acquisition in uncircumcised men may relate to a more thinly keratinized inner foreskin. However, published data are contradictory and potentially confounded by medical indications for circumcision.
Minh H Dinh, Taha Hirbod, Godfrey Kigozi, Eneniziaogochukwu A Okocha, Gianguido C Cianci, Xiangrong Kong, Jessica L Prodger, Kristina Broliden, Rupert Kaul, David Serwadda, Maria J Wawer, Ronald H Gray, Thomas J Hope   +12 more
doaj   +1 more source

Pre-Clinical Evaluation of Tenofovir and Tenofovir Alafenamide for HIV-1 Pre-Exposure Prophylaxis in Foreskin Tissue

Pharmaceutics, 2022
Background: HIV-1 pre-exposure prophylaxis (PrEP) has focused predominantly on protective efficacy in receptive sex, with limited research on the dosing requirements for insertive sex.
Laura Else, Sujan D. Penchala, Azure-Dee Pillay, Thabiso B. Seiphetlo, Limakatso Lebina, Christian Callebaut, Suks Minhas, Roland Morley, Tina Rashid, Neil Martinson, Julie Fox, Saye Khoo, Carolina Herrera   +12 more
doaj   +1 more source

The Penis, the Vagina and HIV Risk: Key Differences (Aside from the Obvious)

Viruses, 2022
Globally, most Human Immunodeficiency Virus type 1 (HIV) transmission occurs through vaginal–penile sex (heterosexual transmission). The local immune environment at the site of HIV exposure is an important determinant of whether exposure during sex will ...
Rupert Kaul, Cindy M. Liu, Daniel E. Park, Ronald M. Galiwango, Aaron A. R. Tobian, Jessica L. Prodger   +5 more
doaj   +1 more source